Stefanova, Nadia and Hainzer, Monika and Stemberger, Sylvia and Couillard-Despres, Sebastien and Aigner, Ludwig and Poewe, Werner and Wenning, Gregor K. (2009) Striatal transplantation for multiple system atrophy - Are grafts affected by alpha-synucleinopathy? EXPERIMENTAL NEUROLOGY, 219 (1). pp. 368-371. ISSN 0014-4886, 1090-2430
Full text not available from this repository. (Request a copy)Abstract
Multiple system atrophy (MSA), a fatal neurodegenerative disorder, is the second most common cause of parkinsonism and frequently associated with autonomic failure. Previous work from our laboratory has shown that striatal grafts survive and exert functional effects in toxin-induced rodent models of MSA-P, the parkinson variant characterized by levodopa resistance due to loss of striatal medium-sized spiny neurons. It is unknown whether oligodendroglial alpha-synuclein signature lesions affect graft survival in MSA. Recent reports on neurotransplantation in Parkinson's disease patients suggest a possible host-to-graft disease propagation of alpha-synuclein pathology which may be relevant to transplantation in MSA as well. We here demonstrate that embryonic E14 striatal allografts show reduced p-zone volume and dopaminergic graft reinnervation accompanied by increased gliosis in a transgenic MSA mouse model featuring alpha-synuclein oligodendrogliopathy. Oligodendrocytes expressing host-specific alpha-synuclein migrate into the graft tissue after 3 months of survival. Our data suggest that the presence of MSA-like alpha-synuclein oligodendrogliopathy and related to it pro-inflammatory microenvironment may compromise the connectivity and neurorestorative outcome of striatal grafts. (C) 2009 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PARKINSONS-DISEASE; NEURONS; PATHOLOGY; PATIENT; Multiple system atrophy; Striatonigral degeneration; alpha-synuclein; Glial cytoplasmic inclusions; Transgenic mouse; Striatal transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Sep 2020 13:17 |
| Last Modified: | 08 Sep 2020 13:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28458 |
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