Dreiseitel, Andrea and Korte, Gabriele and Schreier, Peter and Oehme, Anett and Locher, Sanja and Hajak, Goeran and Sand, Philipp G. (2009) sPhospholipase A(2) is inhibited by anthocyanidins. JOURNAL OF NEURAL TRANSMISSION, 116 (9). pp. 1071-1077. ISSN 0300-9564, 1435-1463
Full text not available from this repository. (Request a copy)Abstract
Epidemiological studies suggest that nutritional antioxidants may reduce the incidence of neurodegenerative disorders and age-related cognitive decline. Specifically, protection against oxidative stress and inflammation has served as a rationale for promoting diets rich in vegetables and fruits. The present study addresses secretory phospholipase A(2) (sPLA(2)) as a novel candidate effector of neuroprotection conferred by anthocyanins and anthocyanidins. Using a photometric assay, 15 compounds were screened for their ability to inhibit PLA(2). Of these, cyanidin, malvidin, peonidin, petunidin, and delphinidin achieved K (i) values a parts per thousand currency sign18 mu M, suggesting a modulatory role for berry polyphenols in phospholipid metabolism.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SECRETORY PHOSPHOLIPASE A(2); NEURODEGENERATIVE DISEASES; ARACHIDONIC-ACID; RAT-BRAIN; DIETARY SUPPLEMENTATION; THERAPEUTIC IMPORTANCE; SELECTIVE-INHIBITION; BEHAVIORAL DEFICITS; OXIDATIVE STRESS; GLIAL-CELLS; Phospholipase A(2); Flavonoids; Anthocyanin; Anthocyanidin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Sep 2020 05:10 |
| Last Modified: | 09 Sep 2020 05:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28502 |
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