Couillard-Despres, Sebastien and Wuertinger, C. and Kandasamy, M. and Caioni, M. and Stadler, K. and Aigner, R. and Bogdahn, U. and Aigner, L. (2009) Ageing abolishes the effects of fluoxetine on neurogenesis. MOLECULAR PSYCHIATRY, 14 (9). pp. 856-864. ISSN 1359-4184, 1476-5578
Full text not available from this repository. (Request a copy)Abstract
Depression constitutes a widespread condition observed in elderly patients. Recently, it was found that several drugs employed in therapies against depression stimulate hippocampal neurogenesis in young rodents and nonhuman primates. As the rate of neurogenesis is dramatically reduced during ageing, we examined the influences of ageing on neurogenic actions of antidepressants. We tested the impact of fluoxetine, a broadly used antidepressant, on hippocampal neurogenesis in mice of three different age groups ( 100, 200 and over 400 days of age). Proliferation and survival rate of newly generated cells, as well as the percentage of cells that acquired a neuronal phenotype were analyzed in the hippocampus of mice that received fluoxetine daily in a chronic manner. Surprisingly, the action of fluoxetine on neurogenesis was decreasing as a function of age and was only significant in young animals. Hence, fluoxetine increased survival and the frequency of neuronal marker expression in newly generated cells of the hippocampus in the young adult group ( that is 100 days of age) only. No significant effects on neurogenesis could be detected in fluoxetine-treated adult and elderly mice (200 and over 400 days of age). The data indicate that the action of fluoxetine on neurogenesis is highly dependent on the age of the treated individual. Although the function of neurogenesis in the clinical manifestation of depression is currently a matter of speculation, this study clearly shows that the therapeutic effects of antidepressants in elderly patients are not mediated by neurogenesis modulation. Molecular Psychiatry (2009) 14, 856-864; doi: 10.1038/mp.2008.147; published online 13 January 2009
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADULT HIPPOCAMPAL NEUROGENESIS; ELEMENT-BINDING PROTEIN; RAT DENTATE GYRUS; CELL-PROLIFERATION; NEUROTROPHIC FACTOR; INCREASES NEUROGENESIS; PSYCHOSOCIAL STRESS; PROGENITOR CELLS; BALB/CJ MICE; VOLUME LOSS; antidepressant; neuronal survival; hippocampus; doublecortin; mouse model |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Sep 2020 05:56 |
| Last Modified: | 09 Sep 2020 05:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28519 |
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