Nishino, Tsuyuki and Ishibashi, K. and Hirtreiter, C. and Nishino, Y. (2009) The prostate growth stimulation by progesterone is due to androgenic products and progesterone receptor-mediated mechanisms. PHARMAZIE, 64 (9). pp. 587-589. ISSN 0031-7144,
Full text not available from this repository. (Request a copy)Abstract
The antiprogestin mifepristone has been demonstrated to inhibit the growth of R3327HI rat prostatic carcinoma. A comparable antitumor effect of onapristone (ON) on rat Dunning tumors was found in our laboratories. We found the localization of progesterone (P4) receptors (PR) in prostate and prostatic tumors. These findings suggest the involvement of P(4) in the mechanism of hormone-dependent growth of prostate and tumors. To study the influence of P4 on the growth of ventral (VP) and dorsolateral prostate (DLP), orchiectomized rats were treated (s.c.) daily with P(4) (0.3, 1.0, 3.0 or 10.0 mg), dihydrotestosterone (DHT, 0.05 mg), estradiol (E(2), 3.0 mu g), ON (3.0 mg), ICI 182780 (1.0 mg) or flutamide (FL, 3.0 mg) for 12 days. One day after the last treatment, animals were sacrificed, and the organ weight of VP and DLP was determined. P(4) increased the organ weight of VP and DLP in a dose-dependent manner. In contrast to DHT, which preferentially stimulated the growth of VP, P(4) led rather to an increase in the weight of DLP. The effect of P(4) on the DLP was enhanced by a simultaneous application of DHT or E(2). The antiprogestin ON and the pure antiestrogen ICI 182780 had no appreciable effect on the P(4)-induced growth of VP and DLP. ON inhibited, however, the E(2)/P(4)-induced growth of DLP without affecting the growth of the VP. In contrast the antiandrogen FL suppressed the stimulatory effect of P(4) on both the VP and DLP. These findings suggest that the stimulatory effect of P(4) on the rat DLP may be partly due to androgenic products derived from P(4) and may be also mediated by PR.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPIDIDYMIS; CARCINOMA; ESTROGEN; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Sep 2020 07:03 |
| Last Modified: | 09 Sep 2020 07:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28531 |
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