Zintl, Maria and Schmitz, Gerd and Hajak, Goeran and Kluenemann, Hans-Hermann (2009) ApoE Genotype and Family History in Patients With Dementia and Cognitively Intact Spousal Controls. AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, 24 (4). pp. 349-352. ISSN 1533-3175,
Full text not available from this repository. (Request a copy)Abstract
Objective: To test that a positive family history and ApoE epsilon 4 genotype are prevalent among dementia patients with onset before 70 years of age compared with healthy spousal controls. Methods: A total of 210 patients with dementia and 82 spousal control participants. Neuropsychiatric examination, Consortium to establish a registry on Alzheimer's disease test battery, Clock-drawing Test, and ApoE genotyping were performed in patients and controls. Results: Of the 131 patients with Alzheimer dementia, 25 were homozygous for Apo epsilon 4. Among dementia patients with a positive family history (n = 83), homozygosity for the Apo epsilon 4 genotype was found in 19 (22.9%). A positive family history was highest among Apo epsilon 4 homozygous Alzheimer dementia patients (72.0%) and lowest among the cognitively normal spousal controls (9.3%). Conclusions: In our sample of patients with Alzheimer dementia, approximately 3 of 4 (72.0%) were homozygous for the genotype Apo epsilon 4 when they had a positive family history.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | APOLIPOPROTEIN-E EPSILON-4; ALZHEIMERS-DISEASE; ONSET; ASSOCIATION; RELATIVES; ALLELE; RISK; AGE; dementia; Alzheimer's disease; ApoE; family history |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Sep 2020 09:59 |
| Last Modified: | 09 Sep 2020 09:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28577 |
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