Seitz, Stephan and Schally, Andrew V. and Treszl, Andrea and Papadia, Andrea and Rick, Ferenc and Szalontay, Luca and Szepeshazi, Karoly and Ortmann, Olaf and Halmos, Gabor and Hohla, Florian and Buchholz, Stefan (2009) Preclinical evaluation of properties of a new targeted cytotoxic somatostatin analog, AN-162 (AEZS-124), and its effects on tumor growth inhibition. ANTI-CANCER DRUGS, 20 (7). pp. 553-558. ISSN 0959-4973, 1473-5741
Full text not available from this repository. (Request a copy)Abstract
In view of findings that various tumors express receptors for somatostatin, a new targeted cytotoxic analog of somatostatin, AN-162 (AEZS-124), consisting of doxorubicin linked through glutaric acid to the somatostatin octapeptide RC-121 was developed in our laboratory. We studied the toxicity in vivo and the effect of AN-162 on growth of the MDA-MB-231 estrogen-independent human breast cancer cell line xenografted into nude mice. AN-162 induced significant tumor growth inhibition compared with the control and the group treated with doxorubicin in equimolar doses. We also evaluated the stability of AN-162 in various sera in vitro, as this conjugate is susceptible to hydrolysis by serum carboxylesterase enzymes in the circulation. This study shows for the first time that AN-162 is a safe and effective compound for the treatment of experimental breast cancer. Our findings support the concept of targeted chemotherapy based on cytotoxic peptide analog AN-162 for the treatment of breast cancers and other cancers expressing somatostatin receptors. Anti-Cancer Drugs 20:553-558 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HORMONE-RELEASING HORMONE; HUMAN OVARIAN CANCERS; HUMAN BREAST-CANCER; IN-VITRO; 500-1000 TIMES; MOUSE MODEL; DOXORUBICIN; RECEPTORS; THERAPY; POTENT; AN-162; breast cancer; doxorubicin; half-life; somatostatin; targeted therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Sep 2020 07:15 |
| Last Modified: | 10 Sep 2020 07:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28583 |
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