Stritzke, Jan and Linsel-Nitschke, Patrick and Paulista Markus, Marcello Ricardo and Mayer, Bjoern and Lieb, Wolfgang and Luchner, Andreas and Doering, Angela and Koenig, Wolfgang and Keil, Ulrich and Hense, Hans-Werner and Schunkert, Heribert (2009) Association between degenerative aortic valve disease and long-term exposure to cardiovascular risk factors: results of the longitudinal population-based KORA/MONICA survey. EUROPEAN HEART JOURNAL, 30 (16). pp. 2044-2053. ISSN 0195-668X, 1522-9645
Full text not available from this repository. (Request a copy)Abstract
Degenerative aortic valve disease (DAVD), a common finding in the elderly, is associated with an increased risk of death due to cardiovascular causes. Taking advantage of its longitudinal design, this study evaluates the prevalence of DAVD and its temporal associations with long-term exposure to cardiovascular risk factors in the general population. We studied 953 subjects (aged 25-74 years) from a random sample of German residents. Risk factors had been determined at a baseline investigation in 1994/95. At a follow-up investigation, 10 years later, standardized echocardiography determined aortic valve morphology and aortic valve area (AVA) as well as left ventricular geometry and function. At the follow-up study, the overall prevalence of DAVD was 28%. In logistic regression models adjusting for traditional cardiovascular risk factors at baseline age (OR 2.0 [1.7-2.3] per 10 years, P < 0.001), active smoking (OR 1.7 [1.1-2.4], P = 0.009) and elevated total cholesterol levels (OR 1.2 [1.1-1.3] per increase of 20 mg/dL, P < 0.001) were significantly related to DAVD at follow-up. Furthermore, age, baseline status of smoking, and total cholesterol level were significant predictors of a smaller AVA at follow-up study. In contrast, hypertension and obesity had no detectable relationship with long-term changes of aortic valve structure. In the general population we observed a high prevalence of DAVD that is associated with long-term exposure to elevated cholesterol levels and active smoking. These findings strengthen the notion that smoking cessation and cholesterol lowering are promising treatment targets for prevention of DAVD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LEFT-VENTRICULAR MASS; CLINICAL-SIGNIFICANCE; FIBROUS SKELETON; LOWERING THERAPY; POMERANIA SHIP; STENOSIS; PROGRESSION; CALCIFICATION; HEALTH; ECHOCARDIOGRAPHY; Epidemiology; Degenerative aortic valve disease; Risk factor; Cholesterol; Smoking |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Sep 2020 07:26 |
| Last Modified: | 10 Sep 2020 07:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28613 |
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