Hendig, Doris and Langmann, Thomas and Zarbock, Ralf and Schmitz, Gerd and Kleesiek, Knut and Goetting, Christian (2009) Characterization of the ATP-binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line. MOLECULAR AND CELLULAR BIOCHEMISTRY, 328 (1-2). pp. 85-92. ISSN 0300-8177, 1573-4919
Full text not available from this repository. (Request a copy)Abstract
Chemotherapy failure was reported in treatment of retinoblastoma suggesting a role for ATP-binding cassette (ABC) proteins. Little is known about the expression pattern of ABC proteins in this cancer type. We investigated the gene expression profile of 47 ABC proteins in the human retinoblastoma cell line Y79 by TaqMan low-density array. Analysis revealed 31 ABC transporter genes expressed in this tumor cell line. Y79 cells demonstrate high gene expression of ABCA7, ABCA12, ABCB7, ABCB10, ABCC1, ABCC4, ABCD3, ABCE1, ABCF1, ABCF2, and ABCF3 (more than twofold compared to pooled RNA from different tissues). Moreover, we show that Y79 cells exhibit an active calcein efflux pointing to multidrug resistance protein (MRP)-like transporter activity. In summary, we present for the first time an ABC transporter gene expression profile in cells derived from retinoblastoma. Most of the highly expressed ABC transporter genes are typical markers of cancer cells and might exhibit potential targets for medical treatment of retinoblastoma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MULTIDRUG-RESISTANCE PROTEIN; ABC TRANSPORTER; P-GLYCOPROTEIN; PSEUDOXANTHOMA ELASTICUM; MRP; PATHOGENESIS; SUPERFAMILY; FIBROBLASTS; SUBSTRATE; INTERACTS; ABC transporter; ABC protein; Gene expression; Retinoblastoma; Y79 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Sep 2020 08:03 |
| Last Modified: | 10 Sep 2020 08:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28654 |
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