Martinetz, Stefanie (2016) MicroRNA's impact on neurotransmitter and neuropeptide systems: small but mighty mediators of anxiety. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 468 (6). pp. 1061-1069. ISSN 0031-6768, 1432-2013
Full text not available from this repository. (Request a copy)Abstract
Psychiatric disorders rank among the most common severe diseases worldwide, with millions of people affected worldwide every year. The symptoms are manifold, and the outcome for the patients is often unclear. As a high and yearly rising cost burden for society, anxiety disorders, depression and their related mental disorders are currently a well-researched topic in order to develop new functional pharmacological therapies as alternatives to those that are in use and bear many unpleasant side effects. Brain circuitries, such as those underlying anxiety formations, are mainly driven by the interplay of various neurotransmitter systems and the interaction of different brain loci, as well as the modulating impact of neuropeptides. Targeting those networks is a complex but promising way to regulate mood. Alterations on molecular level of the neuronal cell in response to respective receptor activation, especially at post-transcriptional level via the highly regulatory function of non-coding RNAs such as microRNAs (miRNAs) seem to hold a promising future in the development of novel therapeutic strategies and are therefore under intensified investigation. This review focusses on the impact of miRNAs on the neurotransmitter and neuropeptide systems of the central nervous system relevant for the formation of anxiety disorders and discusses the potential of miRNAs for the development of new therapeutic strategies for anxiety and mood disorders.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADULT NEUROGENESIS; PREFRONTAL CORTEX; PHARMACOLOGICAL-TREATMENT; TRANSPORTER EXPRESSION; SEROTONIN TRANSPORTER; HIPPOCAMPAL-NEURONS; ENRICHED MICRORNA; MAJOR DEPRESSION; EUROPE 2010; DISORDERS; Anxiety disorder; MicroRNA; Neuropeptide; Neurotransmitter; Serotonin |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 02 Sep 2020 06:11 |
| Last Modified: | 02 Sep 2020 06:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2869 |
Actions (login required)
 |
View Item |
