Safety and immunogenicity of concomitant vaccination with the cell-culture based Japanese Encephalitis vaccine IC51 and the hepatitis A vaccine HAVRIX (R) 1440 in healthy subjects: A single-blind, randomized, controlled Phase 3 study

Kaltenboeck, A. and Dubischar-Kastner, K. and Eder, G. and Jilg, W. and Klade, C. and Kollaritsch, H. and Paulke-Korinek, M. and von Sonnenburg, F. and Spruth, M. and Tauber, E. and Wiedermann, U. and Schuller, E. (2009) Safety and immunogenicity of concomitant vaccination with the cell-culture based Japanese Encephalitis vaccine IC51 and the hepatitis A vaccine HAVRIX (R) 1440 in healthy subjects: A single-blind, randomized, controlled Phase 3 study. VACCINE, 27 (33). pp. 4483-4489. ISSN 0264-410X, 1873-2518

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Abstract

In travellers often several pre-departure immunizations are indicated, thus data are needed about possible interactions between vaccines. This Phase 3 study investigated the immunogenicity and safety of IC51 (JE vaccine) and HAVRIX (R) 1440 (hepatitis A vaccine) when administered alone or concomitantly to healthy subjects. The immune response was compared between single and concomitant vaccination in terms of geometric mean titre (GMT) and seroconversion rate (SCR) on Days 28 and 56. Immunogenicity was comparable for the 2 vaccines whether given together or separately which suggests that travellers to such regions could receive the vaccinations concomitantly. (C) 2009 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: ANTIBODY; POPULATION; Concomitant vaccination; IC51; Japanese encephalitis; Travel; Hepatitis A; Interaction
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Depositing User: Dr. Gernot Deinzer
Date Deposited: 10 Sep 2020 09:37
Last Modified: 10 Sep 2020 09:37
URI: https://pred.uni-regensburg.de/id/eprint/28701

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