Gnewuch, Carsten and Liebisch, Gerhard and Langmann, Thomas and Dieplinger, Benjamin and Mueller, Thomas and Haltmayer, Meinhard and Dieplinger, Hans and Zahn, Alexandra and Stremmel, Wolfgang and Rogler, Gerhard and Schmitz, Gerd (2009) Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. WORLD JOURNAL OF GASTROENTEROLOGY, 15 (25). pp. 3134-3141. ISSN 1007-9327, 2219-2840
Full text not available from this repository. (Request a copy)Abstract
AIM: To determine free and conjugated serum bileacid (BA) levels in inflammatory bowel disease (IBD) subgroups with defined clinical manifestations. METHODS: Comprehensive serum BA profiling was performed in 358 IBD patients and 310 healthy controls by liquid chromatography coupled to electrospray ionization tandem mass spectrometry. RESULTS: Serum levels of hyodeoxycholic acid, the CYP3A4-mediated detoxification product of the secondary BA lithocholic acid (LCA), was increased significantly in Crohn's disease (CD) and ulcerative colitis (UC), while most other serum BA species were decreased significantly. Total BA, total BA conjugate, and total BA glycoconjugate levels were decreased only in CD, whereas total unconjugated BA levels were decreased only in UC. In UC patients with hepatobiliary manifestations, the conjugated primary BAs glycocholic acid, taurocholic acid, and glycochenodeoxycholic acid were as significantly increased as the secondary BAs LCA, ursodeoxycholic acid, and tauroursodeoxycholic acid compared to UC patients without hepatobiliary manifestations. Finally, we found that in ileocecal resected CD patients, the unconjugated primary BAs, cholic acid and chenodeoxycholic acid, were increased significantly compared to controls and patients without surgical interventions. CONCLUSION: Serum BA profiling in IBD patients that indicates impaired intestinal barrier function and increased detoxification is suitable for advanced diagnostic characterization and differentiation of IBD subgroups with defined clinical manifestations. (C) 2009 The WIG Press and Baishideng. All rights reserved. AIM: To determine free and conjugated serum bile
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PRIMARY SCLEROSING CHOLANGITIS; CHOLESTATIC LIVER-DISEASE; PREGNANE-X-RECEPTOR; CROHNS-DISEASE; URSODEOXYCHOLIC ACID; ULCERATIVE-COLITIS; NUCLEAR RECEPTORS; METABOLISM; MECHANISMS; ABSORPTION; Bile acids; Liquid chromatography; Tandem mass spectrometry; Inflammatory bowel disease; Crohn's disease; Ulcerative colitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Sep 2020 10:31 |
| Last Modified: | 10 Sep 2020 10:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28711 |
Actions (login required)
 |
View Item |
