Pawlik, Michael T. and Schubert, Thomas and Hopf, Susanne and Lubnow, Matthias and Gruber, Michael and Selig, Christoph and Taeger, Kai and Ittner, Karl P. (2009) The Effects of Fenoterol Inhalation After Acid Aspiration-Induced Lung Injury. ANESTHESIA AND ANALGESIA, 109 (1). pp. 143-150. ISSN 0003-2999,
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: Acid aspiration is a serious complication that can Occur during general anesthesia. Studies show that beta-agonists have beneficial effects on lung injury. Therefore, we tested the effect of the nebulized beta-agonist fenoterol on lung variables in a rodent model of acid-induced lung injury. METHODS: In a prospective, randomized, and controlled Study, we evaluated the effects of fenoterol inhalation on lung oxygenation, inflammation, and pulmonary histology in a rat model of acid-induced lung injury. Sprague-Dawley rats underwent sevoflurane anesthesia with tracheotomy and carotid catheter insertion. Lung injury was induced by instillation of 0.4 mL/kg 0.1, M hydrochloric acid. The lungs were ventilated for 6 h and randomized to receive either fenoterol inhalation 10 mu g or saline inhalation, both at 15 and 1.80 min after acid aspiration. Mean arterial blood pressures and peak airway pressures were documented, arterial blood gases were determined at 30, 90, 180, 270, and 360 min, and postmortem histology was subsequently examined. Additionally, fenoterol concentrations in bronchoalveolar lavage fluid (BALF) and plasma were determined by liquid chromatography/tandem mass spectroscopy. After 360 min tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 were determined in the BALF, and lungs were dried for determination of the wet/dry ratio. RESULTS: Inhalation treatment with 10 mu g fenoterol significantly increased oxygenation after 270 and 360 mien when compared with placebo. Fenoterol-treated rats showed a significant decrease in IL-6 and TNF-alpha levels and in the wet/dry weight ratio of the lungs. The histologic appearance showed significantly less interstitial edema and leukocyte infiltration in the fenoterol group. The concentration of fenoterol was 10.3 mu g/L (median) in the BALF and <1 mu g/L in the plasma. CONCLUSIONS: Fenoterol inhalation improved oxygenation after 270 and 360 min, attenuated the release of TNF-alpha and IL-6, and diminished the lung edema and infiltration of polymorphonuclear leukocytes. (Anesth Analg 2009;109:143-50)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; ALVEOLAR FLUID CLEARANCE; FACTOR-ALPHA; ADRENERGIC AGONISTS; RAT LUNGS; EDEMA; HYPEROXIA; CELLS; ISOPROTERENOL; INFLAMMATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Sep 2020 10:51 |
| Last Modified: | 10 Sep 2020 10:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28718 |
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