Hersberger, Martin and Mueller, Martina and Marti-Jaun, Jacqueline and Heid, Iris M. and Coassin, Stefan and Young, Thomas F. and Waechter, Vanessa and Hengstenberg, Christian and Meisinger, Christine and Peters, Annette and Koenig, Wolfgang and Holmer, Stephan and Schunkert, Heribert and Klopp, Norman and Kronenberg, Florian and Illig, Thomas (2009) No association of two functional polymorphisms in human ALOX15 with myocardial infarction. ATHEROSCLEROSIS, 205 (1). pp. 192-196. ISSN 0021-9150,
Full text not available from this repository. (Request a copy)Abstract
The 12/15-lipoxygenase plays a janus-role in inflammation with pro-inflammatory and anti-inflammatory effects in cell systems and even opposite effects on atherosclerosis in two different animal species. Screening of the human 15-lipoxygenase (ALOX15) gene detected a polymorphic C to T substitution at position c.-292, which led to three times higher ALOX15 activity in macrophages and showed a trend to be atheroprotective in a small case-control study for coronary artery disease (CAD). A second polymorphism at position c.1693C>T leading to an T560M exchange and an inactive enzyme was recently associated with increased CAD. We now investigated whether these polymorphisms ora certain haplotype of ALOX15 are associated with myocardial infarction (MI) in a case-control subset from the population-based MONIKA/KORA cohort S3. Six polymorphisms in ALOX15 were analyzed in 2629 participants to cover all major haplotypes with a frequency higher than 1% in the Caucasian population. None of the polymorphism was associated with MI but a rare ALOX15 haplotype showed a significant protective effect on the risk for MI (p=0.03). However, none of the polymorphisms or haplotypes was associated with CRP levels. These data suggest that ALOX15 may play a less prominent role during later stages of atherosclerosis involving atherothrombotic mechanisms than eventually during early plaque development. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACETYLCHOLINE-INDUCED HYPOTENSION; CORONARY-ARTERY-DISEASE; LOW-DENSITY-LIPOPROTEIN; E-DEFICIENT MICE; 15-LIPOXYGENASE; GENE; ATHEROSCLEROSIS; MACROPHAGES; INVOLVEMENT; RABBITS; 15-Lipoxygenase; 12-Lipoxygenase; 15-LOX; 12-LOX; ALOX15; ALOX12; Inflammation; Atherosclerosis; Myocardial infarction; Genetics; Haplotype; Polymorphism |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Sep 2020 13:16 |
| Last Modified: | 10 Sep 2020 13:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28723 |
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