Klein, Christoph A. and Stoecklein, Nikolas H. (2009) Lessons from an Aggressive Cancer: Evolutionary Dynamics in Esophageal Carcinoma. CANCER RESEARCH, 69 (13). pp. 5285-5288. ISSN 0008-5472, 1538-7445
Full text not available from this repository. (Request a copy)Abstract
Rapid progression to metastatic disease and an intrinsic resistance to any type of systemic therapy are hallmarks of aggressive solid cancers. The molecular basis for this phenotype is not clear. A detailed study of the somatic progression from local to early systemic esophageal cancer revealed rapid diversification of cancer cells isolated from various sites, but also evidence for early clonal expansion. These findings have implications for diagnostic pathology and therapeutic decision making. [Cancer Res 2009;69(13):5285-8]
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW MICROMETASTASES; LYMPH-NODE MICROMETASTASIS; DISSEMINATED TUMOR-CELLS; PROGNOSTIC VALUE; ESOPHAGOGASTRIC JUNCTION; ADENOCARCINOMA; METASTASES; CHEMORADIOTHERAPY; PROGRESSION; THERAPY |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Onkogenomik |
| Depositing User: | Petra Gürster |
| Date Deposited: | 19 Feb 2025 09:18 |
| Last Modified: | 19 Feb 2025 09:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28730 |
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