Timmer, Antje and Kemptner, Daniela and Takses, Angela and Klebl, Frank and Joeckel, Karl-Heinz (2009) A survey-based index was validated for measuring disease activity in inflammatory bowel disease. An evaluation study. JOURNAL OF CLINICAL EPIDEMIOLOGY, 62 (7). pp. 771-778. ISSN 0895-4356,
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Objective: Crohn's disease is a highly distressful chronic disorder, characterized by frequent relapses. A symptom-based disease activity index was developed for use in epidemiological research. Study Design and Setting: One hundred and six consecutive patients presenting to a tertiary referral hospital in Southern Germany in 2004-2005 participated in a questionnaire-based survey. As a reference standard, disease activity was assessed using a clinical index (Crohn's Disease Activity Index [CDAI], based on symptoms reported to physician, laboratory markers, and physician assessed signs). A linear regression equation was calculated based on the survey data on severity of symptoms (dependent variable: CDAI). Survey index scores (S-CDAI) were then calculated using the estimated coefficients for pain, stools, and general well-being in an independent data set. Results: S-CDAI and CDAI showed moderate agreement (kappa = 0.57 for relapse vs. remission). High activity (high S-CDAI) correlated negatively with high quality of life (disease specific: Short Inflammatory Bowel Disease Quality-of-Life Questionnaire; r = -0.67; generic: Short Form 36 physical summary score, r = -0.47). Test-retest reliability and sensitivity for change were good (intraclass correlation coefficient 0.81). Conclusion: A useful, valid, and reliable disease activity score was developed, which will facilitate meaningful survey research in this chronic disorder. (C) 2009 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUALITY-OF-LIFE; CROHNS-DISEASE; CLINICAL-TRIALS; SEXUAL FUNCTION; END-POINTS; QUESTIONNAIRE; PREVALENCE; THERAPY; Crohn's disease; Epidemiologic methods; Health status; Questionnaires/standards; Reproducibility of results; Severity of illness index |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2020 05:14 |
| Last Modified: | 14 Sep 2020 05:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28759 |
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