Madry, Henning and Kon, Elizaveta and Condello, Vincenzo and Peretti, Giuseppe M. and Steinwachs, Matthias and Seil, Romain and Berruto, Massimo and Engebretsen, Lars and Filardo, Giuseppe and Angele, Peter (2016) Early osteoarthritis of the knee. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 24 (6). pp. 1753-1762. ISSN 0942-2056, 1433-7347
Full text not available from this repository. (Request a copy)Abstract
There is an increasing awareness on the importance in identifying early phases of the degenerative processes in knee osteoarthritis (OA), the crucial period of the disease when there might still be the possibility to initiate treatments preventing its progression. Early OA may show a diffuse and ill-defined involvement, but also originate in the cartilage surrounding a focal lesion, thus necessitating a separate assessment of these two entities. Early OA can be considered to include a maximal involvement of 50 % of the cartilage thickness based on the macroscopic ICRS classification, reflecting an OARSI grade 4. The purpose of this paper was to provide an updated review of the current status of the diagnosis and definition of early knee OA, including the clinical, radiographical, histological, MRI, and arthroscopic definitions and biomarkers. Based on current evidence, practical classification criteria are presented. As new insights and technologies become available, they will further evolve to better define and treat early knee OA. Level of evidence IV.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUPERFICIAL ZONE PROTEIN; BODY-MASS INDEX; ARTICULAR-CARTILAGE; RADIOGRAPHIC PROGRESSION; BIOCHEMICAL MARKERS; BONE; BIOMARKERS; REPAIR; PAIN; ASSOCIATION; OA; Pain; Osteochondral unit; Cartilage; Subchondral bone; Meniscus; Traumatic lesion; Classification; Focal cartilage defect; Biomarkers |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Mar 2019 10:11 |
| Last Modified: | 21 Mar 2019 10:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2877 |
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