Riquelme, Paloma and Goevert, Felix and Geissler, Edward K. and Faendrich, Fred and Hutchinson, James A. (2009) Human transplant acceptance-inducing cells suppress mitogen-stimulated T cell proliferation. TRANSPLANT IMMUNOLOGY, 21 (3). pp. 162-165. ISSN 0966-3274, 2210-3384
Full text not available from this repository. (Request a copy)Abstract
The Transplant Acceptance-inducing Cell (TAIC) is a form of immunoregulatory macrophage which appears to be capable of establishing a state of alloantigen-specific partial tolerance of solid organ transplants in renal transplant recipients. This report establishes that human TAICs do not elicit a proliferative response from co-cultured allogeneic T cells. More significantly, it has been shown that TAICs are able to suppress proliferation of allogeneic CD4(+) and CD8(+) T cells after mitogenic stimulation. This suppressive activity can be attributed to the deletion of activated T cells by TAICs and to the secretion of a soluble inhibitor of T cell proliferation. It is further shown that the acquisition of T cell-suppressive properties by human TAICs depends upon an unidentified component of human serum. (C) 2009 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RENAL-TRANSPLANTATION; STEM-CELLS; MACROPHAGES; INDUCTION; TOLERANCE; THERAPY; LONG; Macrophage; TAIC; Cell-based immunotherapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2020 06:42 |
| Last Modified: | 14 Sep 2020 06:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28803 |
Actions (login required)
 |
View Item |
