Schmitz, Gerd and Grandl, Margot (2009) Endolysosomal phospholipidosis and cytosolic lipid droplet storage and release in macrophages. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1791 (6). pp. 524-539. ISSN 1388-1981, 0006-3002
Full text not available from this repository. (Request a copy)Abstract
This review summarizes the current knowledge of endolysosomal and cytoplasmic lipid storage in macrophages induced by oxidized LDL (Ox-LDL), enzymatically degraded LDL (E-LDL) and other atherogenic lipoprotein modifications, and their relation to the adapter protein 3 (AP-3) dependent ABCA1 and ABCG1 cellular lipid efflux pathways. We compare endolysosomal lipid storage caused either through drug induced phospholipidosis, inheritable endolysosomal and cytosolic lipid storage disorders and Ox-LDL or E-LDL induced phagosomal uptake and cytosolic lipid droplet storage in macrophages. Ox-LDL is resistant to rapid endolysosomal hydrolysis and is trapped within the endolysosomal compartment generating lamellar bodies which resemble the characteristics of phospholipidosis. Various inherited lysosomal storage diseases including sphingolipidosis, glycosphingolipidosis and cholesteryl ester storage diseases also present a phospholipidosis phenotype. In contrast E-LDL resembling coreless unesterified cholesterol enriched LDL-particles, with a multilamellar, liposome-like structure, lead to rapid phagosomal degradation and cytosolic lipid droplet accumulation. As a consequence the uptake of E-LDL through type I and type II phagocytosis leads to increased lipid droplet formation and moderate upregulation of ABCA1 and ABCG1 while uptake of Ox-LDL leads to a rapid expansion of the lysosomal compartment and a pronounced upregulation of the ABCA1/ABCG1/AP-3 lipid efflux pathway. (C) 2008 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOW-DENSITY-LIPOPROTEIN; DRUG-INDUCED PHOSPHOLIPIDOSIS; ACTIVATED-RECEPTOR-GAMMA; HUMAN ATHEROSCLEROTIC LESIONS; HERMANSKY-PUDLAK-SYNDROME; PROMOTE CHOLESTEROL EFFLUX; ENZYMATICALLY DEGRADED LDL; ADIPOSE-TISSUE MACROPHAGES; CHANARIN-DORFMAN-SYNDROME; WHITE CARNEAU PIGEONS; Phospholipidosis; E-LDL; Ox-LDL; Lipid droplet; Macrophages; Atherosclerosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 07 Nov 2024 09:24 |
| Last Modified: | 07 Nov 2024 09:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28843 |
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