Lee, Jung Eun and Mannisto, Satu and Spiegelman, Donna and Hunter, David J. and Bernstein, Leslie and van den Brandt, Piet A. and Buring, Julie E. and Cho, Eunyoung and English, Dallas R. and Flood, Andrew and Freudenheim, Jo L. and Giles, Graham G. and Giovannucci, Edward and Hakansson, Niclas and Horn-Ross, Pamela L. and Jacobs, Eric J. and Leitzmann, Michael F. and Marshall, James R. and McCullough, Marjorie L. and Miller, Anthony B. and Rohan, Thomas E. and Ross, Julie A. and Schatzkin, Arthur and Schouten, Leo J. and Virtamo, Jarmo and Wolk, Alicja and Zhang, Shumin M. and Smith-Warner, Stephanie A. (2009) Intakes of Fruit, Vegetables, and Carotenoids and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 18 (6). pp. 1730-1739. ISSN 1055-9965,
Full text not available from this repository. (Request a copy)Abstract
Fruit and vegetable consumption has been hypothesized to reduce the risk of renal cell cancer. We conducted a pooled analysis of 13 prospective studies, including 1,478 incident cases of renal cell cancer (709 women and 769 men) among 530,469 women and 244,483 men followed for up to 7 to 20 years. Participants completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RR) were calculated using the Cox proportional hazards model and then pooled using a random effects model. We found that fruit and vegetable consumption was associated with a reduced risk of renal cell cancer. Compared with <200 g/d of fruit and vegetable intake, the pooled multivariate RR for >= 600 g/d was 0.68 [95% confidence interval (95% CI) = 0.54-0.87; P for between-studies heterogeneity = 0.86; P for trend = 0.001]. Compared with <100 g/d, the pooled multivariate RRs (95% CI) for 400 g/d were 0.79 (0.63-0.99; P for trend = 0.03) for total fruit and 0.72 (0.48-1.08; P for trend = 0.07) for total vegetables. For specific carotenoids, the pooled multivariate RRs (95% CIs) comparing the highest and lowest quintiles were 0.87 (0.73-1.03) for alpha-carotene, 0.82 (0.69-0.98) for beta-carotene, 0.86 (0.73-1.01) for beta-cryptoxanthin, 0.82 (0.64-1.06) for lutein/zeaxanthin, and 1.13 (0.95-1.34) for lycopene. In conclusion, increasing fruit and vegetable consumption is associated with decreasing risk of renal cell cancer; carotenoids present in fruit and vegetables may partly contribute to this protection. (Cancer Epidemiol Biomarkers Prev 2009;18(6):1730-9)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FOOD-FREQUENCY QUESTIONNAIRE; COLORECTAL-CANCER; UNITED-STATES; CALIFORNIA TEACHERS; DIETARY CAROTENOIDS; PROSPECTIVE COHORT; KIDNEY CANCER; MALE SMOKERS; FOLLOW-UP; CARCINOMA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2020 08:58 |
| Last Modified: | 14 Sep 2020 08:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28845 |
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