Gloeckner, Sabine C. and Dhir, Mashaal and Yi, Joo Mi and McGarvey, Kelly E. and Van Neste, Leander and Louwagie, Joost and Chan, Timothy A. and Kleeberger, Wolfram and de Bruine, Adriaan P. and Smits, Kim M. and Bakker, Carolina A. J. Khalid-de and Jonkers, Daisy M. A. E. and Stockbruegger, Reinhold W. and Meijer, Gerrit A. and Oort, Frank A. and Iacobuzio-Donahue, Christine and Bierau, Katja and Herman, James G. and Baylin, Stephen B. and Van Engeland, Marion and Schuebe, Kornel E. and Ahuja, Nita (2009) Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer. CANCER RESEARCH, 69 (11). pp. 4691-4699. ISSN 0008-5472, 1538-7445
Full text not available from this repository. (Request a copy)Abstract
We have used a gene expression array-based strategy to identify the methylation of tissue factor pathway inhibitor 2 (TFPI2), a potential tumor suppressor gene, as a frequent event in human colorectal cancers (CRC). TFPI2 belongs to the recently described group of embryonic cell Polycomb group (PcG)-marked genes that may be predisposed to aberrant DNA methylation in early stages of colorectal carcinogenesis. Aberrant methylation of TFPI2 was detected in almost all CRC adenomas (97%, n = 56) and stages I to IV CRCs (99%, n = 115). We further explored the potential of TFPI2 as a biomarker for the early detection of CRC using stool DNA-based assays in patients with nonmetastatic CRC and average-risk noncancer controls who were candidates for screening. TFPI2 methylation was detected in stool DNA from stage I to III CRC patients with a sensitivity of 76% to 89% and a specificity of 79% to 93%. Detection of TFPI2 methylation in stool DNA may act as a useful adjunct to the noninvasive strategies for screening of CRCs in the future. [Cancer Res 2009;69(11):4691-9]
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR PATHWAY INHIBITOR-2; FECAL OCCULT BLOOD; CHROMATIN PATTERN; CELL FATE; GENE; HYPERMETHYLATION; MUTATIONS; CARCINOMA; POLYPS; MARKER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2020 09:11 |
| Last Modified: | 14 Sep 2020 09:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28847 |
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