Koeck, Franz-Xaver and Bobrik, Verena and Fassold, Alexander and Grifka, Joachim and Kessler, Sigurd and Straub, Rainer H. (2009) Marked Loss of Sympathetic Nerve Fibers in Chronic Charcot Foot of Diabetic Origin Compared to Ankle Joint Osteoarthritis. JOURNAL OF ORTHOPAEDIC RESEARCH, 27 (6). pp. 736-741. ISSN 0736-0266, 1554-527X
Full text not available from this repository. (Request a copy)Abstract
The pathogenesis of Charcot foot is based on three disputed factors: (1) loss of neurotrophic influence, (2) microtraumatic lesions, and (3) neurovascular disturbances. These etiological causes were uncovered by clinicophysiological tests. However, no results of quantitative nerve density studies of sympathetic and sensory substance P-positive (SP+) nerve fibers are available. We studied the density of sympathetic and SP+ nerve fibers in three distinct areas of the tarsus. Fifteen patients with ankle osteoarthritis (OA) and 15 patients with diabetic Charcot foot were included. Patients with OA did not differ from those with Charcot foot in SP+ sensory nerve fiber density. However, at all three areas, the density of sympathetic nerve fibers was significantly lower in patients with Charcot foot compared to OA (p = 0.006). In addition, we found that the sympathetic nerve repellent factor semaphorin 3C was highly expressed in inflamed tissue in Charcot patients. In Charcot foot of diabetic origin a severe loss of sympathetic nerve fibers was observed. These findings in chronically inflamed Charcot foot lend Support to the neurovascular theory in the late chronic phase, which probably depends on the inflammatory upregulation of nerve repellent factors. (C) 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:736-741, 2009
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RHEUMATOID-ARTHRITIS; SYNOVIAL TISSUE; ARTHROPATHY; NEUROPATHY; PATIENT; ULCERATION; AMPUTATION; CRITERIA; RISK; CARE; Charcot; sympathetic nerve fiber; sensory nerve fiber; substance P |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2020 07:47 |
| Last Modified: | 14 Sep 2020 07:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28896 |
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