Vlachy, N. and Touraud, D. and Heilmann, J. and Kunz, W. (2009) Determining the cytotoxicity of catanionic surfactant mixtures on HeLa cells. COLLOIDS AND SURFACES B-BIOINTERFACES, 70 (2). pp. 278-280. ISSN 0927-7765,
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The cytotoxicity of commonly used synthetic surfactants and catanionic mixtures of those was evaluated using MTT on HeLa cells. The 50% inhibition concentration (IC(50)) for MTT reduction was calculated. The effect on chain length increase and inclusion of polyoxyethylene groups on the toxicity was tested on single surfactant systems. A general trend of increasing toxicity with increasing chain length and the presence of polyoxyethylene groups was observed. The measured IC50 values of catanionic systems lie between those of participating surfactants. The increase in toxicity as the cationic surfactant is added to the anionic one is however not linear. A steep decrease of the IC50 values (and therefore increase in the toxic properties) is observed immediately already at low concentrations of the cationic surfactants. This behavior is analogous to the enzyme activity in catanionic microemulsions. (C) 2009 Elsevier B.V. All rights reserved
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SPONTANEOUS VESICLE FORMATION; CORNEAL EPITHELIAL-CELLS; PRIMARY CULTURES; SALT ADDITION; TOXICITY; VALIDATION; TRANSITION; IRRITATION; INVITRO; ASSAYS; Cytotoxicity; Catanionic Mixtures; HeLa cells; Surfactants; Drug delivery |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > Prof. Dr. Werner Kunz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Sep 2020 07:02 |
| Last Modified: | 16 Sep 2020 07:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29029 |
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