Schmaal, L. and Veltman, D. J. and van Erp, T. G. M. and Saemann, P. G. and Frodl, T. and Jahanshad, N. and Loehrer, E. and Tiemeier, H. and Hofman, A. and Niessen, W. J. and Vernooij, M. W. and Ikram, M. A. and Wittfeld, K. and Grabe, H. J. and Block, A. and Hegenscheid, K. and Voelzke, H. and Hoehn, D. and Czisch, M. and Lagopoulos, J. and Hatton, S. N. and Hickie, I. B. and Goya-Maldonado, R. and Kraemer, B. and Gruber, O. and Couvy-Duchesne, B. and Renteria, M. E. and Strike, L. T. and Mills, N. T. and de Zubicaray, G. I. and McMahon, K. L. and Medland, S. E. and Martin, N. G. and Gillespie, N. A. and Wright, M. J. and Hall, G. B. and MacQueen, G. M. and Frey, E. M. and Carballedo, A. and van Velzen, L. S. and van Tol, M. J. and van der Wee, N. J. and Veer, I. M. and Walter, H. and Schnell, K. and Schramm, E. and Normann, C. and Schoepf, D. and Konrad, C. and Zurowski, B. and Nickson, T. and McIntosh, A. M. and Papmeyer, M. and Whalley, H. C. and Sussmann, J. E. and Godlewska, B. R. and Cowen, P. J. and Fischer, F. H. and Rose, M. and Penninx, B. W. J. H. and Thompson, P. M. and Hibar, D. P. (2016) Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group. MOLECULAR PSYCHIATRY, 21 (6). pp. 806-812. ISSN 1359-4184, 1476-5578
Full text not available from this repository. (Request a copy)Abstract
The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited statistical power, disease heterogeneity and the complex interactions between clinical characteristics and brain morphology. To address this, we meta-analyzed three-dimensional brain magnetic resonance imaging data from 1728 MDD patients and 7199 controls from 15 research samples worldwide, to identify subcortical brain volumes that robustly discriminate MDD patients from healthy controls. Relative to controls, patients had significantly lower hippocampal volumes (Cohen's d=-0.14, % difference=-1.24). This effect was driven by patients with recurrent MDD (Cohen's d=-0.17, % difference=-1.44), and we detected no differences between first episode patients and controls. Age of onset <= 21 was associated with a smaller hippocampus (Cohen's d=-0.20, % difference=-1.85) and a trend toward smaller amygdala (Cohen's d=-0.11, % difference=-1.23) and larger lateral ventricles (Cohen's d=0.12, % difference=5.11). Symptom severity at study inclusion was not associated with any regional brain volumes. Sample characteristics such as mean age, proportion of antidepressant users and proportion of remitted patients, and methodological characteristics did not significantly moderate alterations in brain volumes in MDD. Samples with a higher proportion of antipsychotic medication users showed larger caudate volumes in MDD patients compared with controls. This currently largest worldwide effort to identify subcortical brain alterations showed robust smaller hippocampal volumes in MDD patients, moderated by age of onset and first episode versus recurrent episode status.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VOXEL-BASED MORPHOMETRY; UNIPOLAR DEPRESSION; HIPPOCAMPAL VOLUME; AMYGDALA VOLUME; ONSET DEPRESSION; METAANALYSIS; STRESS; MATTER; ABNORMALITIES; SEGMENTATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2019 14:00 |
| Last Modified: | 25 Mar 2019 14:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2907 |
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