Hoves, S. and Aigner, M. and Pfeiffer, C. and Laumer, M. and Obermann, E. C. and Mackensen, Andreas (2009) In situ analysis of the antigen-processing machinery in acute myeloid leukaemic blasts by tissue microarray. LEUKEMIA, 23 (5). pp. 877-885. ISSN 0887-6924, 1476-5551
Full text not available from this repository. (Request a copy)Abstract
Altered expression of major histocompatibility complex (MHC) class I molecules can be caused by defects in genes of the antigen-processing machinery (APM), and is often correlated to progression in solid tumours. However, little is known about expression of the APM components in blasts from patients with acute myeloid leukaemia (AML). In this study, we investigated the expression of the APM components large multifunctional peptidases (LMP) 2 and 7, transporter-associated with antigen processing (TAP) 1 and 2, beta-2-microglobulin (beta 2m) and MHC class I heavy chain in situ by tissue microarray from bone marrow biopsies of 30 AML patients. APM components were heterogeneously expressed in all AML samples tested, but no significant correlation with the AML subtype according to the French-American-British classification was found. Depending on the APM component tested, up to 90% of the trephines showed no or weak expression, whereas the LMP7 protein was detected in 66% of all samples. By following disease progression in individual AML patients, we found severe downregulation of APM components in two out of four patients from initial diagnosis to relapse. We conclude that downregulation of APM components may play a role in the failure of immunosurveillance and may therefore contribute to relapse in acute leukaemia. Leukemia 2009) 23, 877-885; doi:10.1038/leu.2008.391; published online 15 January 2009
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MHC CLASS-I; RENAL-CELL CARCINOMA; IMMUNE ESCAPE; MALIGNANT-CELLS; DOWN-REGULATION; MELANOMA-CELLS; HUMAN TUMORS; T-CELLS; EXPRESSION; PEPTIDE; acute myeloid leukaemia; tissue microarray; antigen-processing machinery |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Sep 2020 12:40 |
| Last Modified: | 16 Sep 2020 12:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29079 |
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