Elbakry, Asmaa and Zaky, Alaa and Liebkl, Renate and Rachel, Reinhard and Goepferich, Achim and Breunig, Miriam (2009) Layer-by-Layer Assembled Gold Nanoparticles for siRNA Delivery. NANO LETTERS, 9 (5). pp. 2059-2064. ISSN 1530-6984, 1530-6992
Full text not available from this repository. (Request a copy)Abstract
Although uptake into cells is highly complex and regulated, heterogeneous particle collectives are usually employed to deliver small interfering RNA (siRNA) to cells. Within these collectives, it is difficult to accurately identify the active species, and a decrease in efficacy is inherent to such preparations. Here, we demonstrate the manufacture of uniform nanoparticles with the deposition of siRNA on gold in a layer-by-layer approach, and we further report on the cellular delivery and siRNA activity as functions of surface properties.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FUNCTIONAL CORE/SHELL NANOPARTICLES; MAMMALIAN-CELLS; GENE-REGULATION; DNA COMPLEXES; QUANTUM DOTS; OLIGONUCLEOTIDES; THERAPEUTICS; POLYPLEXES; ANTISENSE; SIZE; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Sep 2020 07:29 |
| Last Modified: | 17 Sep 2020 07:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29082 |
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