Dreiseitel, Andrea and Korte, Gabriele and Schreier, Peter and Oehme, Anett and Locher, Sanja and Domani, Martina and Hajak, Goeran and Sand, Philipp G. (2009) Berry anthocyanins and their aglycons inhibit monoamine oxidases A and B. PHARMACOLOGICAL RESEARCH, 59 (5). pp. 306-311. ISSN 1043-6618,
Full text not available from this repository. (Request a copy)Abstract
Monoamine oxidases (MAO) are mitochondrial enzymes that catalyze the oxidation of monoamines in multiple tissues, including the brain. Elevated MAO activity has long been implicated in the etiology of depression, anxiety, and neurodegenerative disease, fuelling the search for inhibitors in the prevention and treatment of these disorders. We hypothesized that emerging neuroprotective effects of anthocyanins from berry fruits may be explained by an affinity of these polyphenols for MAO isoforms A or B. Using a luminometric MAO assay, 25 anthocyanidins, anthocyanidin-3-glycosides, anthocyanidin-3,5-diglucosides, proanthocyanidins, and phenolic metabolites were examined. For MAO A and B, IC50 values in the low micromolar range were reached by anthocyanidins and anthocyanidin-3-glycosides. as opposed to values in the low millimolar range for phenolic acids. Kinetic analyses, performed with cyanidin and cyanidin-3-glucoside, indicated a competitive interaction of cyanidin with MAO A plus a mixed competitive and non-competitive mode of interaction of cyanidin with MAO B and of cyanidin-3-glucoside with both enzyme isoforms. Thus anthocyanins and their aglycons achieve MAO inhibition in vitro that is compatible with central nervous functionalities. For extrapolation of the present findings to in vivo effects, future studies will need to address in more detail the bioavailability of these dietary constituents. (C) 2009 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUANTITATIVE ENZYME AUTORADIOGRAPHY; HUMAN PERIPHERAL-TISSUES; MAO-B; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; IN-VITRO; NEURODEGENERATIVE DISEASES; SELECTIVE-INHIBITION; BEHAVIORAL DEFICITS; SCAVENGING ACTIVITY; Anthocyanin; Anthocyanidin; Flavonoid; MAO A; MAO B |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Sep 2020 08:40 |
| Last Modified: | 17 Sep 2020 08:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29092 |
Actions (login required)
 |
View Item |
