Driemel, Oliver and Ettl, Tobias and Koelbl, Oliver and Reichert, Torsten E. and Dresp, Bernd V. and Reuther, Juergen and Pistner, Hans (2009) Outcome and Histopathologic Regression in Oral Squamous Cell Carcinoma after Preoperative Radiochemotherapy. STRAHLENTHERAPIE UND ONKOLOGIE, 185 (5). pp. 296-302. ISSN 0179-7158, 1439-099X
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Background and Purpose: Preoperative radiochemotherapy has been reported to enhance tumor response and to improve long-term survival in advanced squamous cell carcinoma of the head and neck. This retrospective study evaluates regression rate and long-term survival in 228 patients with primary oral squamous cell carcinoma treated by neoadjuvant radiochemotherapy and radical surgery. Patients and Methods: All patients with biopsy-proven, resectable oral squamous cell carcinoma - TNM stages II-IV without distant metastasis - received preoperative treatment consisting of fractioned irradiation of the primary and the regional lymph nodes with a total dose of 40 Gy and additional cisplatin (n = 160) or carboplatin ( n = 68) during the 1st week of treatment. Radical surgery and neck dissection followed after a delay of 10 - 14 days. The study only included cases with histologically negative resection margins. Results: After a median follow-up of 5.2 years, 53 patients (23.2%) had experienced local-regional recurrence. The median 2-year disease-specific survival (DSS) rate was 86.2%. 5-year DSS and 10-year DSS were 76.3% and 66.7%, respectively. Complete histological local tumor regression after surgery (ypT0) was observed in 50 patients (21.9%) and was independent of pretreatment tumor classification. Uni- and multivariate survival analysis revealed that ypT- and ypN-stage were the most decisive predictors for DSS. Conclusion: Preoperative radiochemotherapy with cisplatin/carboplatin followed by radical surgery attains favorable long-term survival rates. This applies especially to cases with complete histological tumor regression after radiochemotherapy, which can be assumed for one of five patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHASE-II TRIAL; LOCALLY ADVANCED HEAD; PLUS RADICAL SURGERY; NECK-CANCER; OROPHARYNGEAL CANCER; NEOADJUVANT RADIOCHEMOTHERAPY; CONCURRENT CHEMORADIOTHERAPY; RADIATION-THERAPY; HYPERFRACTIONATED RADIOTHERAPY; PROGNOSTIC-FACTOR; Oral squamous cell carcinoma; Preoperative radiochemotherapy; Cis-/carboplatin; Histological regression; Survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Sep 2020 09:14 |
| Last Modified: | 17 Sep 2020 09:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29105 |
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