Schneidewind, Arne and Brumme, Zabrina L. and Brumme, Chanson J. and Power, Karen A. and Reyor, Laura L. and O'Sullivan, Kristin and Gladden, Adrianne and Hempel, Ursula and Kuntzen, Thomas and Wang, Yaoyu E. and Oniangue-Ndza, Cesar and Jessen, Heiko and Markowitz, Martin and Rosenberg, Eric S. and Sekaly, Rafick-Pierre and Kelleher, Anthony D. and Walker, Bruce D. and Allen, Todd M. (2009) Transmission and Long-Term Stability of Compensated CD8 Escape Mutations. JOURNAL OF VIROLOGY, 83 (8). pp. 3993-3997. ISSN 0022-538X, 1098-5514
Full text not available from this repository. (Request a copy)Abstract
Human immunodeficiency virus effectively evades CD8(+) T-cell responses through the development of CD8 escape mutations. Recent reports documenting reversion of transmitted mutations and the impact of specific escape mutations upon viral replication suggest that complex forces limit the accumulation of CD8 escape mutations at the population level. However, the presence of compensatory mutations capable of alleviating the impact of CD8 escape mutations on replication capacity may enable their persistence in an HLA-mismatched host. Herein, we illustrate the long-term stability of stereotypic escape mutations in the immunodominant HLA-B27-restricted epitope KK10 in p24/Gag following transmission when accompanied by a specific compensatory mutation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMMUNODEFICIENCY-VIRUS TYPE-1; T-CELL RESPONSES; ACUTE/EARLY HIV-1 INFECTION; VIRAL LOAD; LYMPHOCYTE RESPONSE; CYCLOPHILIN-A; GAG PROTEIN; EVOLUTION; REVERSION; ASSOCIATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Sep 2020 06:34 |
| Last Modified: | 18 Sep 2020 06:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29127 |
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