Hoffmann, U. and Bergler, T. and Rihm, M. and Pace, C. and Krueger, B. and Ruemmele, P. and Stoelcker, B. and Banas, B. and Maennel, D. N. and Kraemer, B. K. (2009) Upregulation of TNF Receptor Type 2 in Human and Experimental Renal Allograft Rejection. AMERICAN JOURNAL OF TRANSPLANTATION, 9 (4). pp. 675-686. ISSN 1600-6135, 1600-6143
Full text not available from this repository. (Request a copy)Abstract
An important role of TNF interacting with TNFR2 has been shown in different models of ischemic, nephrotoxic and immune-mediated renal injury. To systematically evaluate the expression of TNFR2 in renal allograft rejection, we investigated human renal allograft biopsies and, in addition, established an experimental transplantation model in rats to verify the human data under standardized conditions. The expression of TNFR2 was analyzed in 96 human renal allograft biopsies with different disease entities. In a 6-day and a 28-day experimental protocol, TNFR2 was examined in kidney specimens and in the urine of control, uni-nephrectomized and transplanted rats +/- cyclosporine treatment (n = 114). In human biopsies and in rat allografts on day 6 with acute allograft rejection, significantly elevated expression of TNFR2 was observed in tubular epithelial cells, podocytes, B cells and monocytes/macrophages. The expression level was associated with renal function. The TNFR2 expression level at day 28 was significantly lower compared to day 6. TNFR2 is markedly upregulated both in human and experimental acute renal allograft rejection. Our data are robust and consistent between different species, suggesting a role for TNFR2 in the early course of rejection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; TUBULAR EPITHELIAL-CELLS; VERSUS-HOST-DISEASE; RHEUMATOID-ARTHRITIS; KIDNEY-TRANSPLANTATION; SOLUBLE RECEPTORS; GENE-EXPRESSION; DENDRITIC CELLS; GRAFT-SURVIVAL; T-LYMPHOCYTES; Allograft rejection; human and experimental kidney transplantation; immunohistochemistry; mRNA analysis; renal function; TNFR2 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Sep 2020 08:38 |
| Last Modified: | 18 Sep 2020 08:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29141 |
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