Durner, J. and Kreppel, H. and Zaspel, J. and Schweikl, H. and Hickel, R. and Reichl, Franz X. (2009) The toxicokinetics and distribution of 2-hydroxyethyl methacrylate in mice. BIOMATERIALS, 30 (11). pp. 2066-2071. ISSN 0142-9612,
Full text not available from this repository. (Request a copy)Abstract
The cytotoxicity of dental composites has been attributed to the release of residual monomers from polymerized resin-based composites due to the degradation processes or the incomplete polymerisation of materials. 2-Hydroxyethyl methacrylate (HEMA) is one of the major components released from dental resin-based composites. It was shown in vitro that HEMA was released into the adjacent biophase from such materials during the first days after placement. In this study uptake, distribution, and excretion of 14C-HEMA applied via gastric tube or subcutaneous administration at dose levels well above those encountered in dental care were examined in mice to test the hypothesis that HEMA can reach cytotoxic levels in mammalian tissues. 14C-HEMA was taken up rapidly from the stomach and intestines after gastric administration and was widely distributed in the body following administration by each route. Most 14C was excreted within one day as (14)CO(2). Two metabolic pathways of 14C-HEMA can be described. The peak HEMA levels in all tissues examined after 24 h were lower than known toxic levels. Therefore the study did not support the hypothesis. (C) 2008 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN GINGIVAL FIBROBLASTS; DENTAL RESTORATIVE MATERIALS; IN-VITRO; RESIN MONOMERS; CELL-DEATH; ROS PRODUCTION; HEMA; METABOLISM; CYTOTOXICITY; COMPONENTS; Dental restorative material; Biocompatibility; Biodegradation; Composite |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie > Prof. Dr. rer. nat. Helmut Schweikl |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Sep 2020 08:44 |
| Last Modified: | 18 Sep 2020 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29146 |
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