Szeimies, Rolf-Markus and Matheson, Robert T. and Davis, Steven A. and Bhatia, Ashish C. and Frambach, Yvonne and Kloevekorn, Winfried and Fesq, Heike and Berking, Carola and Reifenberger, Julia and Thaci, Diamant (2009) Topical Methyl Aminolevulinate Photodynamic Therapy Using Red Light-Emitting Diode Light for Multiple Actinic Keratoses: A Randomized Study. DERMATOLOGIC SURGERY, 35 (4). pp. 586-592. ISSN 1076-0512, 1524-4725
Full text not available from this repository. (Request a copy)Abstract
Photodynamic therapy (PDT) is an effective treatment for actinic keratoses (AKs). Light-emitting diodes (LEDs) offer practical advantages when treating multiple lesions. To evaluate the efficacy and tolerability of PDT using a LED and topical methyl aminolevulinate (MAL) for treatment of multiple AKs. One hundred thirty-one patients with four to 10 non-pigmented, previously untreated thin or moderately thick AKs on the face or scalp were enrolled in this multicenter, double-blind, randomized, placebo-controlled study. MAL or matching placebo cream was applied to the dEbrided lesion surface for 3 hours before illumination with noncoherent red light (630 nm, light dose 37 J/cm(2)). Treatment was repeated 1 week later. Efficacy was evaluated in 57 patients with 418 lesions treated with MAL PDT and 58 with 414 lesions treated with placebo PDT. Sixteen patients were excluded as protocol violators (not randomized). MAL PDT was superior (p <.001) to placebo PDT in lesion complete response rates (83.3%, 95% confidence interval (CI)=79.3-86.7%, vs 28.7%, 95% CI=24.4-33.4%) and patient complete response rates (all lesions showing complete response; 68.4%, 95% CI=54.8-80.1% vs 6.9%, 95% CI=1.9-16.7%). Topical MAL PDT using a LED is an effective treatment for multiple AKs. This study was supported by Photocure, ASA.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NONMELANOMA SKIN-CANCER; MULTICENTER; CRYOTHERAPY; GUIDELINES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Sep 2020 08:57 |
| Last Modified: | 18 Sep 2020 08:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29154 |
Actions (login required)
 |
View Item |
