Pawlik, Michael T. and Lubnow, Matthias and Gruber, Michael and Taeger, Kai and Riegger, Guenter and Pfeifer, Michael and Ittner, Karl P. (2009) Hydrochloric acid aspiration increases right ventricular systolic pressure in rats. EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 26 (4). pp. 285-292. ISSN 0265-0215,
Full text not available from this repository. (Request a copy)Abstract
Background and objective Pulmonary aspiration of gastric acid is a serious complication during anaesthesia and may cause aspiration pneumonitis and adult respiratory distress syndrome. The development of pulmonary hypertension may aggravate the initial course of the aspiration pneumonitis. The authors hypothesized that acid aspiration induces an acute increase in right ventricular pressure in the rat heart. Additionally, it was hypothesized as a secondary study that endothelin levels would be increased in this rat model. Methods Male Sprague Dawley rats, anaesthetized with sevoflurane, underwent tracheostomy, and catheters were inserted into the carotid and right ventricle. Lung injury was induced by instillation of 0.4 ml kg(-1) 0.1 mol l(-1) HCl; a control group received the same volume of 0.9% NaCl. Rats were then ventilated for 6 hours. p(a)O(2), mean arterial blood pressures and right ventricular systolic pressures were documented every 30 minutes, and arterial blood gases were measured at baseline, 30, 90, 180, 270 and 360 min. Wet/dry ratio was performed and additionally endothelin-1 levels were examined before and 180 and 360 min after aspiration. Results p(a)O(2) values were lower, whereas right ventricular systolic pressures were significantly higher in the HCl group. Mortality rate was 50% after HCl aspiration, whereas 100% of the rats survived NaCl aspiration. Wet/dry ratio and endothelin-1 levels showed a significant increase after 180 and 360 min of HCl aspiration. Conclusion Acid aspiration induces a significant increase in right ventricular systolic pressure and endothelin levels, and causes metabolic acidosis in this animal model. Eur J Anaesthesiol 26:285-292 (c) 2009 European Society of Anaesthesiology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; RESPIRATORY-DISTRESS-SYNDROME; ATRIAL-NATRIURETIC-PEPTIDE; INDUCED LUNG INJURY; PULMONARY-HYPERTENSION; RECEPTOR BLOCKADE; FACTOR-ALPHA; ENDOTHELIN-1; INFLAMMATION; PNEUMONITIS; acid aspiration; acute lung injury; endothelin-1; pulmonary artery hypertension; rats; right ventricular catheter; right ventricular systolic pressure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Sep 2020 09:04 |
| Last Modified: | 18 Sep 2020 09:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29158 |
Actions (login required)
 |
View Item |
