Reber, Stefan O. and Siebler, Philip H. and Donner, Nina C. and Morton, James T. and Smith, David G. and Kopelman, Jared M. and Lowe, Kenneth R. and Wheeler, Kristen J. and Fox, James H. and Hassell, James E. and Greenwood, Benjamin N. and Jansch, Charline and Lechner, Anja and Schmidt, Dominic and Uschold-Schmidt, Nicole and Fuechsl, Andrea M. and Langgartner, Dominik and Walker, Frederick R. and Hale, Matthew W. and Perez, Gerardo Lopez and Van Treuren, Will and Gonzalez, Antonio and Halweg-Edwards, Andrea L. and Fleshner, Monika and Raison, Charles L. and Rook, Graham A. and Peddada, Shyamal D. and Knight, Rob and Lowry, Christopher A. (2016) Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113 (22). E3130-E3139. ISSN 0027-8424,
Full text not available from this repository. (Request a copy)Abstract
The prevalence of inflammatory diseases is increasing in modern urban societies. Inflammation increases risk of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may protect against negative stress-related outcomes. We show that stress disrupts the homeostatic relationship between the microbiota and the host, resulting in exaggerated inflammation. Repeated immunization with a heat-killed preparation of Mycobacterium vaccae, an immunoregulatory environmental microorganism, reduced subordinate, flight, and avoiding behavioral responses to a dominant aggressor in a murine model of chronic psychosocial stress when tested 1-2wk following the final immunization. Furthermore, immunization with M. vaccae prevented stress-induced spontaneous colitis and, in stressed mice, induced anxiolytic or fear-reducing effects as measured on the elevated plus-maze, despite stress-induced gut microbiota changes characteristic of gut infection and colitis. Immunization with M. vaccae also prevented stress-induced aggravation of colitis in a model of inflammatory bowel disease. Depletion of regulatory T cells negated protective effects of immunization with M. vaccae on stress-induced colitis and anxiety-like or fear behaviors. These data provide a framework for developing microbiome- and immunoregulation-based strategies for prevention of stress-related pathologies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC PSYCHOSOCIAL STRESS; INFLAMMATORY-BOWEL-DISEASE; REGULATORY T-CELLS; MESSENGER-RNA EXPRESSION; DORSAL RAPHE NUCLEUS; EARLY-LIFE STRESS; SEROTONERGIC NEURONS; HELICOBACTER-PYLORI; SOCIAL STRESS; INTESTINAL MICROBIOTA; anxiety; chronic psychosocial stress; fear; microbiota; posttraumatic stress disorder |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2019 08:35 |
| Last Modified: | 20 Mar 2019 08:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2917 |
Actions (login required)
 |
View Item |
