Treeck, Oliver and Elemenler, Esma and Kriener, Christina and Horn, Felicitas and Springwald, Anette and Hartmann, Arndt and Ortmann, Olaf (2009) Polymorphisms in the promoter region of ESR2 gene and breast cancer susceptibility. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 114 (3-5). pp. 207-211. ISSN 0960-0760,
Full text not available from this repository. (Request a copy)Abstract
Genetic variations like single nucleotide polymorphisms (SNPs) in genes involved in estrogen biosynthesis, metabolism and signal transduction have been suggested to affect breast cancer susceptibility. In this study we tested the hypothesis that polymorphisms in the promoter of ESR2 gene may be associated with increased risk for breast cancer. We analyzed three SNPs in the promoter region of human ESR2 gene by means of allele-specific tetra-primer PCR. A total of 318 sporadic breast cancer cases and 318 age-matched controls were included in the study. With regard to homozygous genotypes, women with sporadic breast cancer more frequently carried the CC genotype of ESR2 promoter SNP rs2987983 (OR 1.99, p = 0.005). Calculation of allele positivity demonstrated that presence of T allele of this SNP was more frequent in healthy women. Our data suggest that a SNP in the promoter region of ESR2 gene might be able to affect breast cancer risk. These results further support the emerging hypothesis that ER beta is an important factor in breast cancer development. (C) 2009 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ESTROGEN-RECEPTOR-BETA; MESSENGER-RNA EXPRESSION; ER-ALPHA; POSTMENOPAUSAL WOMEN; HAPLOTYPE ANALYSIS; ESTRADIOL LEVELS; RISK; ASSOCIATION; VARIANTS; PROSTATE; Breast cancer; Estrogen receptor beta; Single nucleotide polymorphism; Case control study |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Sep 2020 14:28 |
| Last Modified: | 18 Sep 2020 14:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29193 |
Actions (login required)
 |
View Item |
