Klein, Christoph A. (2009) Parallel progression of primary tumours and metastases. NATURE REVIEWS CANCER, 9 (4). pp. 302-312. ISSN 1474-175X, 1474-1768
Full text not available from this repository. (Request a copy)Abstract
Systemic cancer progression is accounted for in two basic models. The prevailing archetype places the engine of cancer progression within the primary tumour before metastatic dissemination of fully malignant cells. The second posits parallel, independent progression of metastases arising from early disseminated tumour cells. This Perspective draws together data from disease courses, tumour growth rates, autopsy studies, clinical trials and molecular genetic analyses of primary and disseminated tumour cells in support of the parallel progression model. consideration of this model urges review of current diagnostic and therapeutic routines.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COMPARATIVE GENOMIC HYBRIDIZATION; HER2-POSITIVE BREAST-CANCER; BONE-MARROW; RANDOMIZED-TRIAL; GROWTH-RATE; GENETIC-HETEROGENEITY; ADJUVANT CHEMOTHERAPY; EPITHELIAL TUMORS; BRAIN METASTASES; NATURAL-HISTORY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Onkogenomik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Sep 2020 15:01 |
| Last Modified: | 18 Sep 2020 15:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29203 |
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