Tyagi, A. and Penzkofer, Alfons and Batschauer, A. and Wolf, E. (2009) Thermal degradation of (6R,S)-5,10-methenyltetrahydrofolate in aqueous solution at pH 8. CHEMICAL PHYSICS, 358 (1-2). pp. 132-136. ISSN 0301-0104, 1873-4421
Full text not available from this repository. (Request a copy)Abstract
The degradation of the folate (6R,S)-5,10-methenyltetrahydrofolate chloride (MTHF-Cl) in aqueous solution at pH 8 at room temperature is studied by absorption spectra measurements. samples with and without the reducing agent beta-mercaptoethanol (beta-ME) both under aerobic and anaerobic conditions are investigated. MTHF-Cl hydrolyses to (6R,S)-10-formyltetrahydrofolate (10-HCO-H4folate) in all four cases. 10-HCO-H4folate oxidizes to 10-formyldihydrofolate (10-HCO-H2folate) under aerobic conditions in the absence of beta-ME. The degradation dynamics is analysed theoretically and conversion rate constants of hydrolysis and oxidation are determined. (c) 2009 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FLUORESCENCE SPECTROSCOPIC CHARACTERIZATION; BLUE-LIGHT PHOTORECEPTORS; FOLIC ACID COENZYMES; COLI DNA PHOTOLYASE; ESCHERICHIA-COLI; FORMYLTETRAHYDROFOLATE SYNTHETASE; ARABIDOPSIS-THALIANA; TETRAHYDROFOLIC ACID; ACTIVE FORMALDEHYDE; HYDROLYSIS; (6R,S)-5,10-Methenyltetrahydrofolate chloride (MTHF-Cl; 5,10-CH+-H4folate-Cl); (6R,S)-10-Formyltetrahydrofolate (10-HCO-H4folate); 10-Formyldihydrofolate (10-HCO-H2folate); 10-Formylfolate (10-HCO-folate); 5-Formyltetrahydrofolate (5-HCO-H4folate); 5,10-Methylenetetrahydrofolate (5,10-CH2-H4folate); Thermal degradation |
| Subjects: | 500 Science > 530 Physics |
| Divisions: | Physics > Institute of Experimental and Applied Physics > Alumni or Retired Professors > Group Alfons Penzkofer |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Sep 2020 06:26 |
| Last Modified: | 21 Sep 2020 06:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29253 |
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