Leitzmann, Michael F. and Koebnick, Corinna and Abnet, Christian C. and Freedman, Neal D. and Park, Yikyung and Hollenbeck, Albert and Ballard-Barbash, Rachel and Schatzkin, Arthur (2009) Prospective Study of Physical Activity and Lung Cancer by Histologic Type in Current, Former, and Never Smokers. AMERICAN JOURNAL OF EPIDEMIOLOGY, 169 (5). pp. 542-553. ISSN 0002-9262, 1476-6256
Full text not available from this repository. (Request a copy)Abstract
Increased physical activity has been associated with decreased lung cancer risk. However, no previous investigation has examined physical activity in relation to lung cancer histologic types by smoking status. The authors investigated these relations in the National Institutes of Health-AARP Diet and Health Study among 501,148 men and women aged 50-71 years at baseline in 1995-1996. During follow-up to 2003, 6,745 lung carcinomas occurred (14.8% small cell, 40.3% adenocarcinoma, 19.7% squamous cell, 6.1% undifferentiated large cell, 7.2% non-small cell not otherwise specified, and 11.8% carcinoma not otherwise specified). Among former smokers, the multivariate relative risks of small cell, adenocarcinoma, squamous cell, and undifferentiated large cell carcinomas comparing the highest with the lowest activity level (>= 5 times/week vs. inactive) were 0.93 (95% confidence interval (CI): 0.67, 1.28), 0.79 (95% CI: 0.67, 0.94), 0.73 (95% CI: 0.57, 0.93), and 0.61 (95% CI: 0.38, 0.98), respectively. Among current smokers, corresponding values were 0.77 (95% CI: 0.58, 1.02), 0.76 (95% CI: 0.61, 0.95), 0.85 (95% CI: 0.65, 1.11), and 1.10 (95% CI: 0.69, 1.78). In contrast, physical activity was unrelated to lung carcinoma among never smokers (P-interaction between physical activity and smoking for total lung carcinomas = 0.002). The inverse findings among former and current smokers in combination with the null results for physical activity among never smokers may point toward residual confounding by cigarette smoking as an explanation for the relations observed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FORCED EXPIRATORY VOLUME; OXIDATIVE STRESS BIOMARKERS; CIGARETTE-SMOKING; IMMUNE FUNCTION; DNA-DAMAGE; FOLLOW-UP; RISK; COHORT; WOMEN; MEN; lung neoplasms; motor activity; neoplasms by histologic type; prospective studies; smoking |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Sep 2020 08:59 |
| Last Modified: | 21 Sep 2020 08:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29295 |
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