Sandner, Beatrice and Pillai, Deepu R. and Heidemann, Robin M. and Schuierer, Gerhard and Mueller, Matthias F. and Bogdahn, Ulrich and Schlachetzki, Felix and Weidner, Norbert (2009) In Vivo High-Resolution Imaging of the Injured Rat Spinal Cord Using a 3.0T Clinical MR Scanner. JOURNAL OF MAGNETIC RESONANCE IMAGING, 29 (3). pp. 725-730. ISSN 1053-1807, 1522-2586
Full text not available from this repository. (Request a copy)Abstract
Purpose: To investigate the feasibility of obtaining high-resolution MR images for the detection of pathological changes occurring in the injured rat spinal cord with a routine clinical 3.0T imaging system. Materials and Methods: Adult female Fischer 344 rats received thoracic spine contusion injuries. In vivo MR imaging was performed on days I and 43 postinjury with a clinical head 3.0T imaging system equipped with a dedicated small animal 4-channel phased array spine surface coil using T2-weighted turbo spin-echo and T1-weighted spin-echo sequences. Results: The acquired images provide good spatial resolution allowing reliable gray/white matter differentiation in the intact spinal cord as well as detection of hemorrhage, edema. and cystic degenerative changes in the injured rat spinal cord as confirmed by correlation with structural alterations in histological sections. Conclusion: Results from the present study demonstrate that a routine clinical MR imaging system can be employed for noninvasive analysis of pathological changes occurring in the injured rat spinal cord and thus might represent a more broadly available, powerful tool to monitor the effects of experimental therapeutic interventions in vivo.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MOUSE; COMPRESSION; HEMORRHAGE; MODEL; magnetic resonance imaging; spinal cord injury; small animal imaging |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Oct 2020 04:59 |
| Last Modified: | 05 Oct 2020 04:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29392 |
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