Moore, Steven C. and Leitzmann, Michael F. and Albanes, Demetrius and Weinstein, Stephanie J. and Snyder, Kirk and Virtamo, Jarmo and Ahn, Jiyoung and Mayne, Susan T. and Yu, Herbert and Peters, Ulrike and Gunter, Marc J. (2009) Adipokine genes and prostate cancer risk. INTERNATIONAL JOURNAL OF CANCER, 124 (4). pp. 869-876. ISSN 0020-7136,
Full text not available from this repository. (Request a copy)Abstract
Adiposity and adipocyte-derived cytokines have been implicated in prostate carcinogenesis. However. the relationship of adipokine gene variants with prostate cancer risk has not been thoroughly investigated. We therefore examined common variants of the IL6, LEP. LEPR, TNF and ADIPOQ genes in relation to prostate cancer in a case-control study nested within a large cohort of Finnish men. The study sample consisted of 1.053 cases of prostate cancer, diagnosed over an average 11 years of follow up, and 1,053 controls matched to the cases on age, intervention group and date of baseline blood draw. Logistic regression was used to model the relative odds of prostate cancer. We also examined genotypes in relation to serum insulin. IGF-1 and IGF-1:IGFBP-3 among 196 controls. Variant alleles at three loci (-14858A > G, - 13973A > C, -13736C > A) in a potential regulatory region of the LEP gene conferred a statistically significant 20% reduced risk of prostate cancer. For example. at the -14858A>G locus, heterozygotes and homozygotes for the A allele had an odds ratio (OR) of prostate cancer of 0.76 [95% confidence interval (CI) 0.62, 0.93] and 0.79 (95% Cl 0.60. 1.04), respectively. At 13288G > A, relative to the GG genotype, the AA genotype was associated with a suggestive increased risk of prostate cancer (OR = 1.29; 95% Cl 0.99,1.67; P(trend) = 0.05). Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes were not associated with prostate cancer. Allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis. (c) 2008 Wiley-Liss. Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; LEPTIN GENE; MOLECULAR-INTERACTIONS; G-2548A POLYMORPHISM; -2548 G/A; OB GENE; OBESITY; REGION; PREVENTION; INSULIN; leptin; adipokines; cytokines prostate cancer; epidemiology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Oct 2020 09:56 |
| Last Modified: | 05 Oct 2020 09:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29472 |
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