Hart, C. and Grassinger, J. and Andreesen, R. and Hennemann, Burkhard (2009) EPO in combination with G-CSF improves mobilization effectiveness after chemotherapy with ifosfamide, epirubicin and etoposide and reduces costs during mobilization and transplantation of autologous hematopoietic progenitor cells. BONE MARROW TRANSPLANTATION, 43 (3). pp. 197-206. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
A successful stem cell harvest is a prerequisite for peripheral blood SCT. We investigated the number of CD34(+) cells mobilized, the number of leukaphereses needed and the expenses of treatment for 28 patients with multiple myeloma randomly assigned to receive either G-CSF alone or G-CSF + EPO for stem cell mobilization after chemotherapy with ifosfamide, epirubicin and etoposide. All patients treated with G-CSF + EPO reached the threshold of 6 x 10(6) CD34(+) cells per kg body weight (kgbw), with a mean of 1.3 leukaphereses. On average 15.4 x 10(6) CD34(+) cells/kgbw were collected. In the G-CSF-alone group, the mean number of leukaphereses was 1.8, and 12.6 x 10(6) CD34(+) cells/kgbw were collected, and two patients failed the threshold. Overall costs per patient for mobilization and leukaphereses were (sic)8339 (G-CSF + EPO) and (sic)8842 (G-CSF). After transplantation, fewer blood transfusions (0.6 versus 1.3, P = 0.05), fewer days on antibiotics (2.3 versus 6.1, P = 0.02) and a shorter hospital stay (15.2 versus 17.8, P = 0.06) were noted in the G-CSF + EPO group resulting in a 19.2% reduction of costs for each transplant (P = 0.018). In summary, EPO improves the mobilization efficiency of G-CSF and so reduces costs of mobilization and SCT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLONY-STIMULATING FACTOR; HIGH-DOSE CHEMOTHERAPY; PERIPHERAL-BLOOD STEM; MULTIPLE-MYELOMA; BONE-MARROW; RANDOMIZED-TRIAL; MESSENGER-RNA; IN-VITRO; ERYTHROPOIETIN; CYCLOPHOSPHAMIDE; stem cells; mobilization; transplantation; erythropoietin; multiple myeloma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Oct 2020 10:48 |
| Last Modified: | 06 Oct 2020 10:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29491 |
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