Ortmann, Olaf and Cufer, Tanja and Dixon, J. Michael and Maass, Nicolai and Marchetti, Paolo and Pagani, Olivia and Pronzato, Paolo and Semiglazov, Vladimir and Spano, Jean-Philippe and Vrdoljak, Eduard and Wildiers, Hans (2009) Adjuvant endocrine therapy for perimenopausal women with early breast cancer. BREAST, 18 (1). pp. 2-7. ISSN 0960-9776, 1532-3080
Full text not available from this repository. (Request a copy)Abstract
Adjuvant treatment with aromatase inhibitors (AIs) improves outcomes in postmenopausal women with hormone-sensitive early breast cancer compared with tamoxifen However AIs should not be used in., premenopausal women because they can paradoxically increase estrogen secretion and may therefore stimulate tumor progression. In perimenopausal women undergoing treatment for breast cancer, it can be difficult to determine true menopausal Status because adjuvant chemotherapy, tamoxifen, and gonadotropin-releasing hormone analogues can induce transient (or permanent) ovarian suppression. How can one determine whether these women are truly postmenopausal and therefore candidates for AI therapy? A panel of experts in the field of endocrine therapy in breast cancer met in Dubrovnik, Croatia, on October 23, 2006, to discuss this clinical dilemma. This report summarizes the conclusions and recommendations that arose from this discussion. (C) 2008 Published by Elsevier Ltd.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PREMENOPAUSAL WOMEN; POSTMENOPAUSAL WOMEN; AROMATASE INHIBITORS; RANDOMIZED-TRIAL; MENOPAUSAL TRANSITION; OVARIAN-FUNCTION; YOUNG-WOMEN; TAMOXIFEN; HORMONE; CHEMOTHERAPY; Adjuvant; Perimenopausal; Breast carcinoma; Endocrine therapy; Ovarian function suppression |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 20 Oct 2022 11:42 |
| Last Modified: | 20 Oct 2022 11:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29492 |
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