Weigert, Johanna and Neumeier, Markus and Wanninger, Josef and Schober, Franziska and Sporrer, Daniela and Weber, Markus and Schramm, Andrea and Wurm, Sylvia and Stoegbauer, Fabian and Filarsky, Michael and Schaeffler, Andreas and Aslanidis, Charalampos and Schoelmerich, Juergen and Buechler, Christa (2009) Adiponectin upregulates monocytic activin A but systemic levels are not altered in obesity or type 2 diabetes. CYTOKINE, 45 (2). pp. 86-91. ISSN 1043-4666, 1096-0023
Full text not available from this repository. (Request a copy)Abstract
Adiponectin is an adipocyte-derived protein with atheroprotective and immunoregulatory function. Adiponectin and activin A reduce foam cell formation and adiponectin activates the p38 MAPK pathway that is well described to induce activin A. Therefore, it was analyzed whether adiponectin alters activin A in primary human monocytes. Adiponectin dose- and time-dependently induced activin A in the supernatant, and the maximal amount was observed after 12 h of incubation. Adiponectin-stimulated release of activin A was blocked by a p38 MAPK inhibitor. Metformin and pioglitazone are drugs frequently used to treat diabetic patients and metformin slightly reduced monocytic activin A release whereas pioglitazone had no effect. Type 2 diabetes is associated with elevated inflammatory systemic cytokines but activin A serum levels were similar in slim probands, overweight controls and type 2 diabetic patients. Furthermore, activin A did not correlate to systemic adiponectin, body mass index, waist to hip ratio or C-reactive protein. These findings indicate that adiponectin upregulates monocytic activin A release via the p38 MAPK pathway, and this may in part explain the immunoregulatory and antiatherosclerotic effects of this adipokine. (C) 2008 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SERUM CONCENTRATIONS; INTERLEUKIN-6 LEVELS; METABOLIC SYNDROME; HUMAN HEPATOCYTES; MACROPHAGES; RECEPTOR; PROTEIN; CELLS; FOLLISTATIN; CYTOKINE; Adiponectin; Monocyte; Activin A; Type 2 diabetes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Oct 2020 11:17 |
| Last Modified: | 06 Oct 2020 11:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29500 |
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