Berres, Marie-Luise and Papen, Sven and Pauels, Katrin and Schmitz, Petra and Zaldivar, Mirko Moreno and Hellerbrand, Claus and Mueller, Tobias and Berg, Thomas and Weiskirchen, Ralf and Trautwein, Christian and Wasmuth, Hermann E. (2009) A functional variation in CHI3L1 is associated with severity of liver fibrosis and YKL-40 serum levels in chronic hepatitis C infection. JOURNAL OF HEPATOLOGY, 50 (2). pp. 370-376. ISSN 0168-8278, 1600-0641
Full text not available from this repository. (Request a copy)Abstract
Background/Aims: YKL-40 is a chitinase-like protein involved in matrix remodelling and a non-invasive fibrosis marker. We assessed whether a functional promoter polymorphism in CHI3L1, encoding YKL-40, is associated with HCV-induced liver fibrosis and influences YKL-40 serum concentrations. Methods:The CHI3L1 - 131G -> C promoter polymorphism was genotyped in two cohorts of HCV infected patients (n = 440) by 5'-endonuclease assays. Histological fibrosis scores and YKL-40 serum levels (ELISA) were associated with CHI3L1 - 131G -> C by quantitative and qualitative genetic analyses and corrected by multivariate analysis. Results: CHI3L1 - 131 G -> C genotype was strongly associated with the stage of liver fibrosis in the screening (n = 265, P = 0.001) and validation cohort (n = 175, P = 0.009). Homozygous carriers of the G allele were protected from severe fibrosis (F3/F4). This association was confirmed after correction for age and gender. Functionally, the G allele was associated with reduced serum levels of YKL-40 in HCV infected patients (P = 0.002). Conclusions: The CHI3L1 promoter polymorphism - 131 G -> C determines YKL-40 serum levels and is associated with the severity of HCV-induced liver fibrosis. These results suggest a functional role of YKL-40 in liver fibrogenesis and should be taken into account when using YKL-40 as a non-invasive fibrosis marker. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHITINASE PROTEIN FAMILY; COLONIC EPITHELIAL-CELLS; MACROPHAGE DIFFERENTIATION; RHEUMATOID-ARTHRITIS; BACTERIAL ADHESION; CARTILAGE; DISEASE; GENE; SUSCEPTIBILITY; INFLAMMATION; Liver fibrosis; YKL-40; Gene polymorphisms |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Oct 2020 06:04 |
| Last Modified: | 07 Oct 2020 06:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29529 |
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