Riener, Marc-Oliver and Wild, Peter J. and Soll, Christopher and Knuth, Alexander and Jin, Boquan and Jungbluth, Achim and Hellerbrand, Claus and Clavien, Pierre-Alain and Moch, Holger and Jochum, Wolfram (2009) Frequent expression of the novel cancer testis antigen MAGE-C2/CT-10 in hepatocellular carcinoma. INTERNATIONAL JOURNAL OF CANCER, 124 (2). pp. 352-357. ISSN 0020-7136, 1097-0215
Full text not available from this repository. (Request a copy)Abstract
Cancer testis (CT) antigens are attractive targets for immunotherapy in cancer patients. Immunohistochemistry was used to study the expression of the CT antigens MAGE-C2/CT-10, MAGE-C1/CT-7, GAGE, MAGE-A4 and NY-ESO-1 in 146 hepatocellular carcinomas, 13 intrahepatic cholangiocarcinomas, 37 extrahepatic cholangiocarcinomas and 32 gallbladder carcinomas. Immunopositivity was correlated with clinicopathological parameters, MHC Class 1 expression, intratumoral CD4(+), CD8(+) and FOXP3(+) T cells and CD163(+) antigen-presenting cells. Of the 146 hepatocellular carcinomas, 34% were positive for MAGE-C2/CT-10, 12% for MAGE-C1/CT-7, 11% for GAGE and 2% for NY-ESO-1, respectively. MHC Class 1 coexpression was identified in almost all CT antigen-positive tumors. The number of intratumoral FOXP3(+) regulatory T cells was increased in CT antigen-positive hepatocellular carcinomas (p < 0.004), suggesting inhibition of immune response in such tumors. Furthermore, MAGE-C1/CT-7 and GAGE positivity was correlated with reduced overall survival in patients with hepatocellular carcinoma (p = 0.03 and 0.01, respectively). Four (13%) gallbladder carcinomas stained positive for MAGE-C2/CT-10, of which 1 tumor (3%) was also positive for NY-ESO-1 and GAGE. CT antigens were not expressed in intra- and extrahepatic cholangiocarcinomas. Our results suggest that MAGE-C2/CT-10 may be a good candidate for peptide vaccination in patients with hepatocellular carcinoma. (C) 2008 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; INTRAHEPATIC CHOLANGIOCARCINOMA; CANCER/TESTIS ANTIGENS; TISSUE MICROARRAYS; TUMOR; GENES; NY-ESO-1; LYMPHOCYTES; LIVER; MAGE; cancer testis gene; cancer testis antigen; hepatocellular carcinoma; cholangiocarcinoma; gallbladder carcinoma; immunotherapy; cancer vaccination |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Oct 2020 09:12 |
| Last Modified: | 07 Oct 2020 09:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29577 |
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