Schiessl, Ina Maria and Hammer, Anna and Riquier-Brison, Anne and Peti-Peterdi, Janos (2016) Just Look! Intravital Microscopy as the Best Means to Study Kidney Cell Death Dynamics. SEMINARS IN NEPHROLOGY, 36 (3). pp. 220-236. ISSN 0270-9295, 1558-4488
Full text not available from this repository. (Request a copy)Abstract
Kidney cell death plays a key role in the progression of life-threatening renal diseases, such as acute kidney injury and chronic kidney disease. Injured and dying epithelial and endothelial cells take part in complex communication with the innate immune system, which drives the progression of cell death and the decrease in renal function. To improve our understanding of kidney cell death dynamics and its impact on renal disease, a study approach is needed that facilitates the visualization of renal function and morphology in real time. Intravital multiphoton microscopy of the kidney has been used for more than a decade and made substantial contributions to our understanding of kidney physiology and pathophysiology. It is a unique tool that relates renal structure and function in a time- and spatial-dependent manner. Basic renal function, such as microvascular blood flow regulation and glomerular filtration, can be determined in real time and homeostatic alterations, which are linked inevitably to cell death and can be depicted down to the subcellular level. This review provides an overview of the available techniques to study kidney dysfunction and inflammation in terms of cell death in vivo, and addresses how this novel approach can be used to improve our understanding of cell death dynamics in renal disease. (C) 2016 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE-RENAL-FAILURE; ISCHEMIA-REPERFUSION INJURY; MULTIPHOTON IMAGING REVEALS; PARIETAL EPITHELIAL-CELLS; ACTIVATED PROTEIN-C; IN-VIVO; ISCHEMIA/REPERFUSION INJURY; LEUKOCYTE RECRUITMENT; OXIDATIVE STRESS; GLOMERULAR-FILTRATION; Intravital multiphoton microscopy; acute kidney injury; chronic kidney disease; regulated cell death; renal dysfunction |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 01 Sep 2020 04:40 |
| Last Modified: | 01 Sep 2020 04:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2964 |
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