Stark, Klaus and Rovensky, Jozef and Blazickova, Stanislava and Grosse-Wilde, Hans and Ferencik, Stanislav and Hengstenberg, Christian and Straub, Rainer H. (2009) Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls. ARTHRITIS RESEARCH & THERAPY, 11 (3): R70. ISSN 1478-6354, 1478-6362
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Introduction Both genetic and environmental factors contribute to rheumatoid arthritis ( RA), a common and complex autoimmune disease. As well as the major susceptibility gene HLA-DRB1, recent genome-wide and candidate-gene studies reported additional evidence for association of single nucleotide polymorphism (SNP) markers in the PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5 loci with RA. This study was initiated to investigate the association between defined genetic markers and RA in a Slovak population. In contrast to recent studies, we included intensively-characterized osteoarthritis (OA) patients as controls. Methods We used material of 520 RA and 303 OA samples in a case-control setting. Six SNPs were genotyped using TaqMan assays. HLA-DRB1 alleles were determined by employing site-specific polymerase chain reaction (PCR) amplification. Results No statistically significant association of TRAF1/C5 SNPs rs3761847 and rs10818488 with RA was detected. However, we were able to replicate the association signals between RA and HLA-DRB1 alleles, STAT4 (rs7574865), PTPN22 (rs2476601) and OLIG3/TNFAIP3 (rs10499194 and rs6920220). The strongest signal was detected for HLA-DRB1*04 with an allelic P = 1.2*10(-13) (OR = 2.92, 95% confidence interval (CI) = 2.18 - 3.91). Additionally, SNPs rs7574865(STAT4) (P = 9.2*10(-6); OR = 1.71, 95% CI = 1.35 2.18) and rs2476601(PTPN22) (P = 9.5*10(-4); OR = 1.67, 95% CI = 1.23 - 2.26) were associated with susceptibility to RA, whereas after permutation testing OLIG3/TNFAIP3 SNPs rs10499194 and rs6920220 missed our criteria for significance (P-corr = 0.114 and P-corr = 0.180, respectively). Conclusions In our Slovak population, HLA-DRB1 alleles as well as SNPs in STAT4 and PTPN22 genes showed a strong association with RA.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SYSTEMIC-LUPUS-ERYTHEMATOSUS; SHARED EPITOPE HYPOTHESIS; GENOME-WIDE ASSOCIATION; RISK; CLASSIFICATION; CRITERIA; ALLELES; REGION; 6Q23; GDF5; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Oct 2020 07:23 |
| Last Modified: | 09 Oct 2020 07:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29640 |
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