Springwald, Anette and Lattrich, Claus and Seitz, Stephan and Ortmann, Olaf and Treeck, Oliver (2009) Single Nucleotide Polymorphisms in Human Gene icb-1 and Breast Cancer Susceptibility. CANCER INVESTIGATION, 27 (6): PII 909799. pp. 669-672. ISSN 0735-7907, 1532-4192
Full text not available from this repository. (Request a copy)Abstract
In this study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) of differentiation-associated human gene icb-1 (C1orf38) may be associated with breast cancer susceptibility. A total of 646 women323 breast cancer cases and just as many controlswere included. Breast cancer patients more frequently carried the homozygous genotype AA of SNP rs1467465 than did healthy women. Analysis of allele positivity revealed that AG or GG genotypes were significantly less frequent in breast cancer patients, suggesting that presence of G allele might have protective effects. Our data suggest that SNP rs1467465 of human gene icb-1 might affect breast cancer susceptibility.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL-LINES; EXPRESSION; ESTROGEN; DIFFERENTIATION; ASSOCIATION; 1ST-INTRON; OVARIAN; RISK; Breast cancer; Single nucleotide polymorphism; icb-1; C1orf38 gene |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Oct 2020 07:52 |
| Last Modified: | 09 Oct 2020 07:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29653 |
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