Drapeau, Jeremy and Verdier, Marie and Touraud, Didier and Kroeckel, Ulla and Geier, Martin and Rose, Andreas and Kunz, Werner (2009) Effective Insect Repellent Formulation in both Surfactantless and Classical Microemulsions with a Long-Lasting Protection for Human Beings. CHEMISTRY & BIODIVERSITY, 6 (6). pp. 934-947. ISSN 1612-1872, 1612-1880
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The aim of this work is to develop a new generation of repellent products with a long-lasting protection based on a natural component. para-menthane-3,8-diol (PMD). The active is first rendered soluble in a surfactant less microemulsion (H2O/(PrOH)-Pr-i/PMD) and then in classical rnicroeniulsions. The presence of sclf-associated nanostructures is detected by dynamic light scattering (DLS). A synergetic system of surfactants (Cremophor (R) RH40 and Texapon (R) N70) is used. Additionally, 2-ethylhexane-1,3-diol and ethyl (-)-(S)-lactate are incorporated. The final product contains. as main components, 46% of H2O, 25% of (PrOH)-Pr-i, 20% of non-H2O-soluble PMD, and only 4% of surfactants. Investigations of lasting protection on human volunteers are carried out using a cage test bioassay protocol and Aedes aegypti mosquitoes. A complete protection of 315 min is found on the test persons using the surfactantless microemulsion. An extension is observed with the final formulation to reach a mean of complete protection of 385 min. This study demonstrates that alternative formulations using a natural active instead of synthetic chemicals like N,N-diethyl-m-methylbenzamide (DEET) can he efficient for human protection against mosquitoes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AEDES-AEGYPTI; MOSQUITO REPELLENT; LACTIC-ACID; DEET; WATER; PENETRATION; EMULSIONS; CUMULANTS; EFFICACY; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > Prof. Dr. Werner Kunz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Oct 2020 06:18 |
| Last Modified: | 12 Oct 2020 06:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29676 |
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