Schwaenen, Carsten and Viardot, Andreas and Berger, Hilmar and Barth, Thomas F. E. and Bentink, Stefan and Doehner, Hartmut and Enz, Martina and Fellers, Alfred C. and Hansmann, Martin-Leo and Hummel, Michael and Kestler, Hans A. and Klapper, Wolfram and Kreuz, Markus and Lenze, Dido and Loeffler, Markus and Moeller, Peter and Mueller-Hermelink, Hans-Konrad and Ott, German and Rosolowski, Maciej and Rosenwald, Andreas and Ruf, Sandra and Siebert, Reiner and Spang, Rainer and Stein, Harald and Truemper, Lorenz and Lichter, Peter and Bentz, Martin and Wessendorf, Swen (2009) Microarray-Based Genomic Profiling Reveals Novel Genomic Aberrations in Follicular War Lymphoma Which Associate with Patient Survival and Gene Expression Status. GENES CHROMOSOMES & CANCER, 48 (1). pp. 39-54. ISSN 1045-2257, 1098-2264
Full text not available from this repository. (Request a copy)Abstract
Follicular lymphoma (FL) is characterized by a large number of chromosomal aberrations. However, their exact genomic extension and involved target genes remain to be determined. For this purpose, we used array-based intermediate-high resolution genomic profiling in combination with Affymetrix (TM) gene expression analysis. Tumor specimens from 128 FL patients were analyzed for the presence of genomic aberrations and the results were correlated to clinical data sets and mRNA expression levels. In 114 (89%) of the 128 analyzed cases, a total of 688 genomic aberrations (384 gains/amplifications and 304 losses) were detected. Frequent genomic aberrations were: - 1p36 (18%), +2p15 (24%), -3q (14%), -6q (25%), +7p (19%), +7q (23%), +8q (14%), -9p (16%), - 11q (15%), +12q (20%), -13q (11%), -17p (16%), +18p (18%), and +18q (28%). Critical segments of these imbalances were delineated to genomic fragments with a minimum size down to 0.2 Mb. By comparison of these with mRNA gene expression data, putative candidate genes were identified. Moreover, we found that deletions affecting the tumor suppressor gene CDKN2A/B on 9p21 were detected in nontransformed FL grade I-II. For this aberration as well as for -6q25 and -6q26, an association with inferior survival was observed. (C) 2008 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | B-CELL LYMPHOMA; DNA COPY NUMBER; CHRONIC LYMPHOCYTIC-LEUKEMIA; MOLECULAR CHARACTERIZATION; CHROMOSOMAL-ABNORMALITIES; MALIGNANT-LYMPHOMA; PROGNOSTIC FACTORS; CONSENSUS REGIONS; BURKITTS-LYMPHOMA; HYBRIDIZATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Oct 2020 08:29 |
| Last Modified: | 12 Oct 2020 08:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29730 |
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