Pfeiler, Georg and Treeck, Oliver and Wenzel, Gitte and Goerse, Regina and Hartmann, Arndt and Schmitz, Gerd and Ortmann, Olaf (2009) Correlation of body mass index and menopausal status with the intra-tumoral estrogen system in invasive breast cancer. GYNECOLOGICAL ENDOCRINOLOGY, 25 (3): PII 910217. pp. 183-187. ISSN 0951-3590, 1473-0766
Full text not available from this repository. (Request a copy)Abstract
Objective. Obesity increases breast cancer risk in post-menopausal women. This is, in part, due to elevated non-glandular aromatase activity, resulting in higher estradiol serum levels. We tested the hypothesis that obesity and menopausal status influence the intra-tumoral estrogen system of breast cancer tissue. Design. Breast cancer tissue and fasting serum were collected from 26 female patients. After microdissection of the frozen samples, RNA was isolated, and expression of estrogen receptor (ER), ER1, ER2, ER5, CYP19 aromatase and steroid sulfatase was measured on mRNA level by means of real time RT-PCR. Fasting estradiol serum levels were analysed by ELISA. Results. Post-menopausal women older than 70 years exhibited a significantly higher expression both of steroid sulfatase and ER than did pre-menopausal women younger than 50 years. We identified a significant positive correlation between body mass index (BMI) and lymphovascular/vascular invasion. A significant inverse correlation between ER and ER2 expression was identified in invasive breast cancer tissue irrespective of BMI or menopausal status. Conclusion. In conclusion, we report an association between menopausal status-but not BMI-and the intra-tumoral expression of steroid sulfatase and ER. Our observation that BMI was associated with invasiveness supports the hypothesis that metabolic factors are able to affect essential features of breast cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RECEPTOR-BETA; STEROID SULFATASE; EXPRESSION; AROMATASE; ALPHA; TRANSCRIPTION; ER-BETA-1; GROWTH; TISSUE; Breast cancer; menopause; body mass index; estrogen receptor; steroid sulfatase |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Oct 2020 09:03 |
| Last Modified: | 12 Oct 2020 09:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29733 |
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